CAS: 37014-08-7; 1-(3-Methoxyphenyl)Thiourea

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CAS号3125-64-2 3-甲氧基异硫氰酸苯酯 | CAS号536-90-3 间氨基苯甲醚 | CAS号21258-09-3 Benzamide,N-[[(... | CAS号27191-09-9 间茴香胺盐酸盐 | CAS号333-20-0 硫氰酸钾 | CAS号54346-87-1 5-甲氧基-2-苯并噻唑胺 | CAS号35576-47-7 methyl N'-(3-me... | CAS号918154-63-9 3-(5-methoxy-1,...

📜3-甲氧基异硫氰酸苯酯置于氨体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应生成1-(间甲氧基苯基)-2-硫脲
参考文献:(3R)-3-氨基-4-(2,4,5-三氟苯基)-N-{4-[6-(2-甲氧基乙氧基)苯并噻唑-2-基]四氢吡喃-4-基}丁酰胺作为有效的二肽基肽酶iv抑制剂,用于治疗2型糖尿病.
标题:(3R)-3-氨基-4-(2,4,5-三氟苯基)-N-{4-[6-(2-甲氧基乙氧基)苯并噻唑-2-基]四氢吡喃-4-基}丁酰胺作为有效的二肽基肽酶iv抑制剂,用于治疗2型糖尿病.
摘要:合成了一系列新颖的3-氨基-N-(4-芳基-1,1-二氧噻吩-4-基)丁酰胺和3-氨基-N-(4-芳基四氢吡喃-4-基)丁酰胺并评估为二肽基肽酶iv (dpp-Iv)抑制剂.掺入6-取代的苯并噻唑基团的衍生物显示出强效的dpp-Iv抑制活性.(3R)-3-氨基-4-(2,4,5-三氟苯基)-N-{4-[6-(2-甲氧基乙氧基)苯并噻唑-2-基]四氢吡喃-4-基}丁酰胺的口服给药( 12U)在口服葡萄糖耐量试验中降低了血糖偏移.
Doi:10.1016/j.Bmcl.2008.09.042

专利信息

专利号:US-4223031-A
优先权日:1978-05-05
标题 :Azolopyrimidinones
发明人：COVINGTON ROBERT R; TEMPLE JR DAVIS L; YEVICH JOSEPH P
权利人:MEAD JOHNSON & CO
摘要:6-(1H-Tetrazol-5-yl)thiozolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo-pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxy-methylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.

专利号:US-4491587-A
优先权日:1978-05-05
标 题 :Tetrazole derivatives
发明人：COVINGTON ROBERT R; TEMPLE JR DAVIS L; YEVICH JOSEPH P
权利人:MEAD JOHNSON & CO
摘要:6-(1_H-Tetrazol-5-yl)thiazolo[3,2-a]pyrimidin-5-ones, 3-(1_H-tetrazol-5-yl)-4_H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo- pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxymethylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.