CAS: 346-34-9; 4-Fluoroindoline-2,3-Dione

3-氟苯胺置于盐酸,硫酸,盐酸羟胺,Sodium Sulfate体系中,化学反应 2.25H,反应生成 4-氟靛红
参考文献:Structural Basis For The Synthesis Of Indirubins As Potent And Selective Inhibitors Of Glycogen Synthase Kinase-3 And Cyclin-Dependent Kinases
标题:Structural Basis For The Synthesis Of Indirubins As Potent And Selective Inhibitors Of Glycogen Synthase Kinase-3 And Cyclin-Dependent Kinases
摘要:Pharmacological Inhibitors Of Glycogen Synthase Kinase-3 (Gsk-3) And Cyclin-Dependent Kinases Have A Promising Potential For Applications Against Several Neurodegenerative Diseases Such As Alzheimer'S Disease. Indirubins,A Family Of Bis-Indoles Isolated From Various Natural Sources,Are Potent Inhibitors Of Several Kinases,Including Gsk-3. Using The Cocrystal Structures Of Various Indirubins With Gsk-3Beta,Cdk2 And Cdk5/p25,We Have Modeled The Binding Of Indirubins Within The Atp-Binding Pocket Of These Kinases. This Modeling Approach Provided Some Insight Into The Molecular Basis Of Indirubins' Action And Selectivity And Allowed Us To Forecast Some Improvements Of This Family Of Bis-Indoles As Kinase Inhibitors. Predicted Molecules,Including 6-Substituted And 5,6-Disubstituted Indirubins,Were Synthesized And Evaluated As Cdk And Gsk-3 Inhibitors. Control,Kinase-Inactive Indirubins Were Obtained By Introduction Of A Methyl Substitution On N1.
DOI:10.1021/jm031016D