CAS: 31690-09-2; (S)-2-(4-((((S)-2-Amino-5-Methyl-4-Oxo-3,4,5,6,7,8-Hexahydropteridin-6-yl)Methyl)Amino)Benzamido)Pentanedioic Acid

上下游产品

CAS号59-30-3 叶酸

Folate置于sodium Tetrahydroborate,Chloro(1,5-Cyclooctadiene)Rhodium(I) Dimer,水,氢气,三氟乙酸,1,2-Bis[(2S,3S,4S,5S)-3,4-Dihydroxyl-2,5-Dimethylphospholanyl]Benzene体系中,用 Aq. Phosphate Buffer,乙醇 作为反应溶剂,20.0~80.0 °C,3.0 Mpa 条件下,反应 36.0H,反应生成 L-5-甲基四氢叶酸
参考文献:L-5-甲基四氢叶酸钙的制备工艺
标题:L-5-甲基四氢叶酸钙的制备工艺
摘要:本发明涉及一种l‑5‑甲基四氢叶酸钙的制备工艺,采用不对称催化加氢将将叶酸还原为(6S)‑四氢叶酸,叶酸的转化率高,(6S)‑四氢叶酸非对映体过量程度高;通过成盐并结晶,可以容易地富集得到具有极高非对映体过量的(6S)‑四氢叶酸中间体,由此最终制得的l‑5‑甲基四氢叶酸钙的收率和纯度高.本发明的催化加氢工艺在工业应用上十分成熟,操作方便;后续的甲基化和成盐步骤易于实施,在提高了产物收率和纯度的情况下,所述制备工艺具有很高的经济价值和实用价值.

专利信息

专利号:US-9090925-B2
优先权日:2006-01-20
标 题:Synthesis of (6S)-5,6,7,8-tetrahydrofolic acid
发明人：JONES JR GERALD S; ST LAURENT JOSEPH P; GOODRICH SCOTT A; MAGUIRE GEORGE
权利人:JONES JR GERALD S; ST LAURENT JOSEPH P; GOODRICH SCOTT A; MAGUIRE GEORGE; CHEMIC LAB INC
摘要:A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA.

专利号:US-2009191610-A1
优先权日:2005-08-18
标 题 :Microorganisms With Increased Efficiency for Methionine Synthesis
发明人：ZELDER OSKAR; HEROLD ANDREA; KLOPPROGGE CORINNA; SCHRODER HARTWIG; HAEFNER STEFAN; HEINZLE ELMAR; WITTMANN CHRISTOPH; KROEMER JENS; PERO JANICE G; YOCUM R ROGERS; PATTERSON THOMAS A; WILLIAMS MARK; HERMAN THERON
权利人:EVONIK DEGUSSA GMBH
摘要:The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.

专利号:US-9885064-B2
优先权日:2008-01-22
标 题 :Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
发明人：BURK MARK J; SCHILLING CHRISTOPHE H; BURGARD ANTHONY P; TRAWICK JOHN D
权利人:GENOMATICA INC
摘要:The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO 2 and/or H 2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO 2 and H 2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO 2 and/or H 2 , alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.

专利号:EP-1645276-A1
优先权日:2004-10-08
标题:Treatment of neurodegenerative disorders
发明人：DURGA JANE; VERHOEF PETRA
权利人:WAGENINGEN CT FOR FOOD SCIENCE
摘要:The present invention is dedicated to the treatment of neurodegenerative disorders, in particular age related cognitive decline and age related hearing loss. These disorders can be alleviated by increasing 10-formyltetrahydrofolate or increasing thymidylate synthesis. The invention is of particular benefit to subjects that are MTHFR 677CT heterozygote and MTHFR 677CC homozygote. n The substance that increases 10-formyltetrahydrofolate or increases thymidylate synthesis is selected from 10-formyltetrahydrofolate, 5-formyltetrahydrofolate, 5,10-methenyltetrahydrofolate, 5,10-methylentetrahydrofolate, methionine, S-adenosylmethionine and poly-glutamate forms of 10-formyltetrahydrofolate, 5-formyltetrahydrofolate, 5,10-methenyltetrahydrofolate and 5,10-methylentetrahydrofolate and the substance may be in an acid or salt or ester form.

专利号:US-2015317458-A1
优先权日:2012-12-06
标 题 :In silico prediction of enhanced nutrient content in plants by metabolic modelling
发明人：LOTZ KATRIN; LEPS MICHAEL; LEMKE RAINER; JUNKER BJOERN; SCHREIBER FALK
权利人:BASF PLANT SCIENCE CO GMBH
摘要:The present invention relates to a method for identifying at least one metabolic conversion step, the modulation of which increases the amount of a metabolite of interest in a plant cell, plant or plant part, said method comprising establishing a stoichiometric network model for the metabolism of the plant cell, plant or plant part including the synthesis pathway for the metabolite of interest, identifying at least one candidate metabolic conversion step by applying at least one algorithm of Growth-coupled Design, and validating the at least one candidate metabolic conversion step by a constraint-based modeling approach in the stoichiometric network model, wherein an increase in the metabolite of interest occurring in said constraint-based modeling approach is indicative for a metabolic conversion step, the modulation of which increases the amount of the metabolite of interest in the plant cell, plant or plant part. The present invention further relates to a method for generating a plant cell, plant or plant part which produces an increased amount of a metabolite of interest when compared to a control, said method comprising identifying a metabolic conversion step, the modulation of which increases a metabolite of interest in a plant cell, plant or plant part, by the method for identifying a metabolic conversion step and modulating the said metabolic conversion step such that the amount of the metabolite of interest is increased in vivo in a plant cell, plant or plant part.

专利号:US-2024318209-A1
优先权日:2023-09-14
标 题 :Genetically engineered bacterium using glucose as substrate for de novo synthesis of vanillin and application thereof