CAS: 2604-39-9; 2-Chloro-5-Nitropyridin-4-Amine

该化合物是一种硝基替代丙烯衍生物,在相邻位置上具有氯和氨基功能组别,该化合物是有机合成的多用途中间体,特别是在制备药品,农用化学品和特殊化学品方面.反应场所的存在能够有选择地发挥作用,使其对建设复杂的七环框架很有价值.其电排硝质组增强了核阴性替代反应的再活动,而氨基基组则提供了进一步衍生的机会.复合体在标准处理条件下表现出稳定性,确保合成应用的可靠性能.其明确界定的结构和纯度使其适合于需要精确分子修改的研究和工业规模进程.

结构式图片

相似化合物

89182-17-2 2897-43-0 2789-25-5

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号14432-13-4 2-氯-4-n-硝基(氨基吡啶) | CAS号14432-12-3 4-氨基-2-氯吡啶 | CAS号4548-45-2 2-氯-5-硝基吡啶 | CAS号7664-93-9 硫酸 | CAS号2586-99-4 5-硝基吡啶-2,4-二胺 | CAS号2589-11-9 6-氯-1H-咪唑并[4,5-c]吡啶 | CAS号89182-17-2 3,4-二氨基-6-氯吡啶 | CAS号127356-26-7 6-甲氧基-3,4-二氨基吡啶 | CAS号127356-38-1 2-甲氧基-5-硝基吡啶-4-胺

合成工艺路线路线简述

    2-氯-4-N-硝基(氨基吡啶)置于硫酸,氨体系中,用 水 用作溶剂,化学反应 0.5H,反应生成2-氯-4-氨基-5-硝基吡啶
    参考文献:Thiophene-Imidazopyridines
    标题:Thiophene-Imidazopyridines
    摘要:该发明涉及按照公式(I)的噻吩-咪唑吡啶化合物,其中取代基和符号如描述中所定义.这些化合物是pik1的抑制剂.

    海关参考信息

    专利信息


    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11622968-B2
    优先权日:2011-03-08
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-10226449-B2
    优先权日:2013-12-20
    标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
    发明人:HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
    权利人:3 V BIOSCIENCES INC
    摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

    专利号:US-11034690-B2
    优先权日:2016-11-11
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-9428502-B2
    优先权日:2012-07-03
    标题:Heterocyclic modulators of lipid synthesis
    发明人:OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
    权利人:3-V BIOSCIENCES INC
    摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

    专利号:US-9809591-B2
    优先权日:2011-03-08
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
    权利人:3-V BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.
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    合成参考文献


    参考文献:10.1055/s-0030-1259007
    摘要:Hanan E, Chan B, Estrada A, Shore D, Lyssikatos J. Mild and General One-Pot Reduction and Cyclization of Aromatic and Heteroaromatic 2-Nitroamines to Bicyclic 2H-Imidazoles. Synlett. 2010 Oct 14;2010(18):2759–64. doi: 10.1055/s-0030-1259007.
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