CAS: 17692-39-6; 4-[3-[4-(Phenoxymethyl)Phenyl]Propyl]Morpholine

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CAS号69156-39-4 1-(chloromethyl... | CAS号139-02-6 苯酚钠 | CAS号55154-44-4 4-oxido-4-[3-[4... | CAS号110-91-8 吗啉 | CAS号69156-40-7 3-[4-(Phenoxyme... | CAS号55154-44-4 4-oxido-4-[3-[4...

合成工艺路线路线简述

    📜1-(氯甲基)-4-(3-氯丙基)苯置于4-甲基-2-戊酮,甲苯体系中,化学反应生成福莫卡因
    参考文献:Oelschlager,Arzneimittel-Forschung/drug Research,1959,Vol. 9,# 5,P. 313-321
    标题:Oelschlager,Arzneimittel-Forschung/drug Research,1959,Vol. 9,# 5,P. 313-321

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    专利信息


    专利号:US-7993390-B2
    优先权日:2002-02-08
    标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
    发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
    权利人:BOSTON SCIENT SCIMED INC
    摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

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    合成参考文献


    参考文献:10.1007/bf03190012
    摘要:Klinger W, Oelschläger H, Rothley D, Karge E, Seeling A. Interaction of chlormezanone enantiomers with rat liver microsomes. European Journal of Drug Metabolism and Pharmacokinetics. 1999 Mar;24(1):63–8. doi: 10.1007/bf03190012.
    摘要:Oelschläger H, Glassl P, Seeling A, Wange J, Listing M, Jung B. [Synthesis and pharmacologic action of chiral fomocaine ((4-[2-methyl-3-(morpholin-4-yl)propyl)benzyl)-phenyl-ether and (4-(1-methyl-3-(morpholin-4-yl)propyl]benzyl)-phenyl-ether). 13. Synthesis of new compounds with local anesthetic action]. Pharmazie. 2001 Aug;56(8):620–5.
    参考文献:10.1021/cn500070w
    摘要:Schoenberger M, Damijonaitis A, Zhang Z, Nagel D, Trauner D. Development of a new photochromic ion channel blocker via azologization of fomocaine. ACS Chem Neurosci. 2014 Jul 16;5(7):514–8.
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