CAS: 16331-45-6; 4-Ethylbenzoylchloride

相似化合物

52710-27-7 21900-62-9 874-60-2

上下游产品

CAS号619-64-7 对乙基苯甲酸 | CAS号622-96-8 4-乙基甲苯 | CAS号79-37-8 草酰氯 | CAS号100-41-4 乙苯 | CAS号937-30-4 对乙基苯乙酮 | CAS号33695-58-8 4-乙基苯甲酰胺 | CAS号51632-28-1 4-乙基苯基乙腈 | CAS号96220-15-4 3-(4-乙基苯基))-3-氧丙腈 | CAS号622-98-0 1-氯-4-乙基苯 | CAS号768-59-2 4-乙基苄醇 | CAS号64357-92-2 4-乙基-4’-甲氧基苯甲酮 | CAS号7364-20-7 4-乙基苯甲酸甲酯 | CAS号112410-23-8 虫酰肼 | CAS号18220-90-1 4-乙基苯甲酮 | CAS号87102-73-6 Benzoyl fluorid...

对乙基苯甲酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,反应生成对乙基苯甲酰氯
参考文献:靶向人类凝血因子xiia和凝血酶的酰化1 H-1,2,4-三唑-5-胺类化合物:常规和微型合成,抗凝血性质和作用机理
标题:靶向人类凝血因子xiia和凝血酶的酰化1 H-1,2,4-三唑-5-胺类化合物:常规和微型合成,抗凝血性质和作用机理
摘要:我们在此报告了常规和微观并行合成的人类凝血因子xiia和凝血酶的选择性抑制剂,这些抑制剂表现出1,2,4-三唑-5-胺骨架.该支架的结构变异允许鉴定衍生物21I(一种有效的fxiia抑制剂29Nm),具有比其他经过测试的丝氨酸蛋白酶更高的选择性,还可以发现化合物21M对凝血酶具有27 Nm的抑制活性.首次证明酰化的1,2,4-三唑-5-胺具有抗凝特性,并具有影响凝血酶和癌细胞诱导的血小板凝集的能力.进行的质谱分析和分子建模使我们能够发现合成的抑制剂与fxiia活性位点之间以前未知的相互作用,从而揭示了fxiia抑制的机理细节.合成的化合物代表了开发新的抗血栓药物或化学工具以研究fxiia和凝血酶在生理和病理过程中的作用的有希望的起点.
Doi:10.1021/acs.Jmedchem.0C01635

专利信息

专利号:WO-2013035102-A1
优先权日:2011-09-05
标 题 :Processes for the preparation of imatinib base and intermediates thereof
发明人：KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.

专利号:WO-2012014114-A1
优先权日:2010-07-30
标 题:Matrix metalloproteinase inhibitors
发明人：KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
权利人:RANBAXY LAB LTD; KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
摘要:The present invention relates to certain hydroxy propionic acid derivatives and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over activation of a matrix metalloproteinase using the compounds.

专利号:US-8318938-B2
优先权日:2006-02-21
标 题:Trans-fused chromenoisoquinolines synthesis and methods for use
发明人：NICHOLS DAVID; WATTS VAL J
权利人:NICHOLS DAVID; WATTS VAL J; PURDUE RESEARCH FOUNDATION
摘要:Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein.

专利号:CN-103553255-A
优先权日:2013-10-31
标题 :A method for treating and utilizing wastewater in the synthesis of tebufenozide insecticide

专利号:CN-103553255-B
优先权日:2013-10-31
标 题 :Method for treating and utilizing wastewater in synthesis of tebufenozide insecticide