CAS: 14900-39-1; (1-Phenylvinyl)Boronic Acid

该化合物是有机有机体化合物,其特征是存在一个乙烯基组和一个附于一个boronic酸功能组的苯性组,该化合物一般是白色的,白色的和白色的固体,在极地有机溶剂中可溶解.其结构结构是碳原子结于一个氢氧化物组和一个烷基,有助于其再活动,特别是形成与二醇和糖的共价结合,使其在各种应用中有用,包括有机合成和药用化学.在处理该化合物时,应注意注意碳酸的可逆结合性,这在生物系统和传感器的开发中意义重大.此外,1-苯乙烯基博罗酸可参与交叉组合反应,如Suzuki-Miyaura的联结,有助于形成碳结.它的独特特性使它在合成药物和农业化学中成为有价值的中间体.在处置该化合物的时候,应注意到安全防范措施,因为所有碳酸都具有潜在的刺激作用,因此在处理该化合物时应注意安全.

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143825-84-7 1150114-41-2 852626-70-1

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Trimethyl borate 1-bromovinylbenzene (1,2-dibromoethyl)benzene styrene di-n-butyl-(α-styrenyl)boronate 4,4,5,5-tetramethyl-2-(1-phenylvinyl)-1,3,2-dioxaborolane 2-(1-phenylethenyl)-1,3,2-dioxaborolane 2-(1-phenylethenyl)-1,3,2-dioxabornane

合成工艺路线路线简述

    📜Alpha-溴苯乙烯置于盐酸,叔丁基锂体系中,用 乙醚,正己烷,水 用作溶剂,化学反应 2.5H,反应生成1-苯基乙烯基硼酸
    参考文献:由 C-h 激活引发的 Rh(III)-催化的环丙烷化反应:配体开发使 N-烯氧邻苯二甲酰亚胺和烯烃的非对映选择性 [2 + 1] 环化成为可能
    标题:由 C-h 激活引发的 Rh(III)-催化的环丙烷化反应:配体开发使 N-烯氧邻苯二甲酰亚胺和烯烃的非对映选择性 [2 + 1] 环化成为可能
    摘要:N-烯氧基邻苯二甲酰亚胺经过 Rh(III) 催化的 C-H 活化引发缺电子烯烃的环丙烷化.建议该反应通过烯烃 C-H 键的定向活化进行,然后进行两次迁移插入,首先穿过缺电子烯烃,然后环化回烯醇部分.新设计的异丙基环戊二烯基配体极大地提高了产率和非对映选择性.
    Doi:10.1021/ja506579T

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    专利信息


    专利号:US-8207337-B2
    优先权日:2007-01-29
    标 题:Reagent for organic synthesis reaction containing organic triol borate salt
    发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
    权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
    摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

    专利号:WO-2012149182-A2
    优先权日:2011-04-27
    标题 :Automated synthesis of small molecules using chiral, non-racemic boronates

    专利号:CN-113105496-A
    优先权日:2021-03-19
    标题 :A method of nickel-catalyzed benzofuran ring-opening synthesis of o-alkenylphenol derivatives

    专利号:US-9096624-B2
    优先权日:2009-06-01
    标 题:Amino pyrimidine anticancer compounds
    发明人：CREW ANDREW P; SHERMAN DAN; APPARI RAMA DEVI; CHEN XIN; CHILUKURI RAMESH; DONG HANQING; FERRARO CATERINA; FOREMAN KENNETH; GUPTA RAMESH C; LI AN-HU; STOLZ KATHRYN M; VOLK BRIAN; ZAHLER ROBERT
    权利人:OSI PHARMACEUTICALS LLC
    摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

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    主要参考文献

    参考标题:A Broad‐spectrum Synthesis Of Tetravinylethylenes
    作者:Kelsey L. Horvath,Christopher G. Newton,Kimberley A. Roper,Jas S. Ward,Michael S. Sherburn |发布日期:2019.3.15
    摘要:Compounds Of The Tetravinylethylene (Tve) Family Is Reported. Ramirez‐type Dibromo‐olefination Of Readily Accessible Penta‐1,4‐dien‐3‐ones Generates 3,3‐dibromo[3]Dendralenes, Which Undergo Twofold Negishi, Suzuki-Miyaura Or Mizoroki-Heck Reactions With A Wide Variety Of Olefinic Coupling Partners. This Route Delivers A Broad Range Of Unsymmetrically Substituted Tetravinylethylenes With Up To Three

    合成参考文献


    摘要:Carboni, B.; Carreaux, F., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 292.
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