CAS: 110-26-9; N,N-Methylenebisacrylamide

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CAS号50-00-0 甲醛 | CAS号107-13-1 丙烯腈 | CAS号924-42-5 N-羟甲基丙烯酰胺 | CAS号107-06-2 1,2-二氯乙烷 | CAS号79-06-1 丙烯酰胺 | CAS号57-55-6 丙二醇 | CAS号4731-53-7 三正辛基膦 | CAS号7664-93-9 硫酸 | CAS号79-10-7 丙烯酸

聚合甲醛,丙烯酰胺置于4-二甲氨基吡啶,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,对苯二酚体系中,用 水 用作溶剂,化学反应 2.5H,以87.54%的收率获得n,N'-亚甲基双丙烯酰胺
参考文献:一种n,N'-亚甲基双丙烯酰胺的合成方法
标题:一种n,N'-亚甲基双丙烯酰胺的合成方法
摘要:本发明涉及一种n,N'‑亚甲基双丙烯酰胺的合成方法,本发明以丙烯酰胺和多聚甲醛为反应原料,采用负载型杂多酸催化剂与酰胺活化试剂协同催化,制备了n,N'‑亚甲基双丙烯酰胺;负载型杂多酸催化剂与酰胺活化试剂的协同使用可在不影响杂多酸催化的情况下,与丙烯酰胺中的羰基相互作用,破坏酰胺键的p‑π共轭体系,提高氨基的亲核性,增强氨基与多聚甲醛的反应活性,大大提高该反应的选择性,从而在不添加大量的水作为反应溶剂的情况下实现原料的高效转化,提高反应产率.本发明使用的杂多酸催化剂固相负载,反应均在固体催化剂表面进行,体系中无大量的酸性溶剂存在,在后处理过程中无需加入碱液中和,简化了后处理步骤并减少了废水的排放.

专利信息

专利号:US-11938187-B2
优先权日:2021-06-10
标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
发明人：LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN
权利人:UNIV CITY HONG KONG
摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.

专利号:US-2005019901-A1
优先权日:2002-01-31
标题 :Methods for synthesis of bio-active nanoparticles and nanocapsules for use in optical bio-disc assays and disc assembly including same
发明人：MATVEEVA EVGENIA; VALENCIA RAMONCITO MAGPANTAY; WERNER MARTINA ELISABETH
摘要:Optical bio-disc assays and synthesis of bio-active nanoparticles and nanocapsules for use therewith. Related methods for synthesis of polymeric nanoparticles for use in disc assays include forming reverse micelles having an outer non-polar shell and an inner polar cavity and solubilizing in the reverse micelles a polymerizing mixture including monomers, co-monomers, weakly polar monomers, and/or polymerizable surfactants. This may also include an initiator of polymerization. The methods also include polymerizing the mixture. The invention is also directed to the use of the nanoparticles and nanocapsules in optical bio-disc assays for the detection of analytes including nucleic acid sequences. Related optical assay discs and disc systems are also provided.

专利号:WO-2024082909-A1
优先权日:2022-10-18
标 题:Detection method for monitoring synthesis of rna by in vitro transcription in real time
发明人：YANG GUANGYU; QIN WEITONG; LI LIANG; YANG FAN
权利人:SHANGHAI SHENDAO BIOTECHNOLOGY CO LTD; UNIV SHANGHAI JIAOTONG
摘要:A detection method for monitoring synthesis of RNA by in vitro transcription in real time, relating to the technical field of molecular biology and transcription. A DNA template suitable for in vitro transcription and a real-time fluorescent transcription system are developed, and a high-throughput, simple and sensitive RNA synthesis monitoring and quantification system is established. The DNA template/real-time fluorescent transcription system/monitoring system can be applied to synthesizing mRNA vaccines, screening RNA polymerases, analyzing promoter strength, screening drugs for inhibiting transcription, optimizing mRNA drug production process, training mRNA drug sequence AI design software and the like, and can further be applied to optimizing an in vitro transcription system, quantifying RNA polymerase activity, and optimizing sequences.

专利号:EP-2742996-A1
优先权日:2012-12-17
标 题 :Sorbents and method for synthesis of sorbents intended for removal of radionuclides and toxic trace elements from water
发明人：KLAVINS MARIS; ABRAMENKOVS ANDRIS; ANSONE LINDA
权利人:UNIV LATVIJAS
摘要:The invention relates to synthesis of sorbents for removal of radionuclides and toxic trace elements (e.g. heavy metals, no-metallic elements and metalloids) from waters. The offered method for synthesis of sorbents provides covering natural biomaterial structure acting as sorbent matrix with a layer of synthetic polymer containing functional groups by graft polymerization. The sorbent matrix is derived from peat, sawdust or straw.

专利号:US-7705136-B2
优先权日:2005-02-25
标 题 :Synthesis of 3′-, or 5′-, or internal methacrylamido-modified oligonucleotides
发明人：GOLOVA JULIA B; CHERNOV BORIS K
权利人:UCHICAGO ARGONNE LLC
摘要:New modifiers were synthesized for incorporation of a methacrylic function in 3′-, 5′- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5′-methacrylated oligonucleotides for preparation of microarrays by a co-polymerization method.

专利号:US-4609707-A
优先权日:1983-11-10
标题 :Synthesis of polymers containing integral antibodies
发明人：NOWINSKI ROBERT C; HOFFMAN ALLAN S
权利人:GENETIC SYSTEMS CORP
摘要:A method is disclosed for the de novo synthesis of antibody-containing polymers and the preparation of a class of polymerizable compounds used in the synthesis of such antibody-containing polymers. Antibody-containing polymers formed from monomer/antibody conjugates and nonderivatized polymerizable compounds can be varied in formation of the polymer to provide control of (a) molecular spacing, steric accessibility and the number of antibody molecules that are integrally incorporated into the polymer backbone, and (b) the chemical and physical structure of the polymer itself, thus enabling specific tailoring of antibody-containing polymers for particular end-use application. Also disclosed is a method for the selective removal of a compound from a solution or suspension thereof using monomer/receptor conjugates where the compound has the capacity to bind to the receptor in the conjugate. The bound compound is removed by polymerization - induced separation of the monomer/receptor--compound complex from solution.