CAS: 76272-36-1; Exo-8-Benzyl-8-Azabicyclo[3.2.1]Octan-3-Amine

上下游产品

CAS号76272-34-9 8-苄基-8-氮杂双环[3.2... | CAS号132259-54-2 tert-butyl (3-e... | CAS号1515-26-0 N-(8-methyl-8-a... | CAS号28957-72-4 N-苄基托品酮 | CAS号542-05-2 1,3-丙酮二羧酸 | CAS号532-24-1 托品酮 | CAS号100-46-9 苄胺 | CAS号850847-96-0 N-benzyl-3-α-(4... | CAS号423165-07-5 (1R,3s,5S)-3-(3... | CAS号376348-70-8 N-叔丁氧羰基-(1S)-3-... | CAS号376348-67-3 N-(8-苄基-8-氮杂双环[... | CAS号423165-13-3 8-苄基-3-外型-(5-异丙... | CAS号132234-68-5 N-[(3-exo)-8-氮杂... | CAS号76351-84-3 2-Amino-N-(8-(p... | CAS号76351-85-4 2-amino-4-metho... | CAS号76351-86-5 2-Amino-4-metho... | CAS号76352-13-1 曲帕必利 | CAS号76352-24-4 5-Pyrimidinecar...

📜Tert-Butyl (3-Exo-8-Benzyl-8-Azabicyclo[3.2.1]oct-3-yl)Carbamate 在 盐酸体系中,用 1,4-二氧六环,甲醇作为反应溶剂,反应 2.0H,以100%的收率获得exo-8-Benzyl-8-Azabicyclo[3.2.1]octan-3-Amine
参考文献:Preparation And Activities Of Macromolecule Conjugates Of The Ccr5 Antagonist Maravir°C
标题:Preparation And Activities Of Macromolecule Conjugates Of The Ccr5 Antagonist Maravir°C
摘要:Ccr5 Antagonists Are Among The Most Advanced Approaches In Hiv Therapy And May Also Be Relevant To Treatment Of Graft-Versus-Host Disease And Staphyloocus Aureus Infection. To Expand The Potential Of The Only Approved Ccr5 Antagonist,Maravir°C,We Studied Derivatives That Would Enable Functional Linkage Of Maravir°C To Long-Lived Carriers. Through Targeted Synthesis,We Discovered An Effective Linkage Site On Maravir°C And Demonstrate The Potential Of These Derivatives To Prepare Potent Chemically Programmed Antibodies And Pegylated Derivatives. The Resulting Compounds Effectively Neutralized A Variety Of Hiv-1 Isolates. Both Chemically Programmed Antibody And Pegylation Approaches Extend The Neutralization Activity Of Serum Circulating Maravir°C. Derivation Of A Successful Conjugation Strategy For Maravir°C Should Further Enable Its Use In Chemically Programmed Vaccines,Novel Bispecific Antibodies,And Topical Microbicides.
Doi:10.1021/Ml400370W