CAS: 75679-58-2; 2',4'-Dihydroxy-4,6'-Dimethoxydihydrochalcone
该化合物是一种二氢恰酮衍生物,其特点是独特的多酚结构,该化合物由于存在多种氢氧基和甲氧功能组,增加了其自由的激进清扫活动,因此具有显著的抗氧化特性,其稳定性和溶性使该化合物适合用于药物和化妆配方,因为氧化性应激反应是关键. 此外,该化合物的结构特征表明在调节炎症途径方面具有潜在的生物活动.其纯度和定义明确的化学特性确保了研究和工业应用的再生性,特别是在侧重于天然产品衍生物及其治疗潜力的研究中.
- 英文名称2',4'-Dihydroxy-4,6'-Dimethoxydihydrochalcone
- 中文名称2',4'-二羟基-4,6'-二甲氧基二氢查尔酮
- IUPAC名称1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-one
- 其它别名2',4'-Dihydroxy-4,6'-Dimethoxydihydrochalcone; 1-Propanone, 1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-(4-Methoxyphenyl)-; 2',4'-Dihydroxy-4',6'-Dimethoxydihydrochalcone
- CAS编号75679-58-2
- MFCD编号:MFCD23103578
- 分子式:C17H18O5分子量:302.33
- 产品CID: 1748656
- 产品分类天然产物 → 查尔酮类化合物
物理性质
MSDS等安全信息
上下游产品
(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 5-methoxyresorcinol 3-(4-methoxyphenyl)propionitrile 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 2',4'-diacetoxy-4,6'-dimethoxydihydr°Chalkone 2'-hydroxy-4,4',6'-trimethoxydihydr°Chalcone 2'-acetoxy-4,4',6'-trimethoxydihydr°Chalkone合成工艺路线路线简述
- 合成目标产物 2',4'-Dihydroxy-4,6'-Dimethoxydihydrochalcone 主要起始原料 2',4'-Dihydroxy-4,6'-Dimethoxychalcone
- (文献来源)合成步骤主要原料 2',4'-Dihydroxy-4,6'-Dimethoxychalcone
📜2',4'-二羟基-4,6'-二甲氧基查尔酮置于5%-Palladium/activated Carbon,氢气体系中,用 乙酸乙酯 作为反应溶剂,20.0 °C,1.72 Mpa 条件下,反应 1.5H,以40.2%的收率获得产物2',4'-二羟基-4,6'-二甲氧基二氢查尔酮
参考文献:新型查耳酮的合成,细胞毒性和抗克氏锥虫活性.
标题:新型查耳酮的合成,细胞毒性和抗克氏锥虫活性.
摘要:合成具有细胞毒性的二氢查耳酮,首先从传统的亚马逊药用植物鸢尾菊中提取(myristicaceae),然后对饱和和不饱和查耳酮合成中间体进行全面的sar分析,从而鉴定出具有选择性和显着体外抗锥虫病的类似物.克鲁兹活动.通过合成21个含有两个烯丙氧基部分的新查耳酮进行了进一步的sar研究,结果发现了2',4'-二烯丙氧基-6'-甲氧基查耳酮,在浓度低于25 Microm时对这种寄生虫具有更高的选择性,其中四个表现出大于12的选择性指数.
DOI:10.1021/jm800812K
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2907221000-对苯二酚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9061984-B2
优先权日:2008-08-15
标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases
发明人：HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM
权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS
摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/0031-9422(96)00352-4
摘要:Tsui W, Brown GD. Cycloeudesmanolides from Sarcandra glabra. Phytochemistry. 1996 Nov;43(4):819–21. doi: 10.1016/0031-9422(96)00352-4.
参考文献:10.1016/s0031-9422(97)00306-3
摘要:Silva DHS, Yoshida M, Kato MJ. Flavonoids from Iryanthera sagotiana. Phytochemistry. 1997 Oct;46(3):579–82. doi: 10.1016/s0031-9422(97)00306-3.
参考文献:10.1107/s1600536805028291
摘要:Ng S, Razak IA, Fun H, Boonsri S, Chantrapromma S, Prawat U. A second monoclinic polymorph of 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-one. Acta Crystallogr E Struct Rep Online. 2005 Sep 14;61(10):o3234–6. doi: 10.1107/s1600536805028291.
参考文献:10.1016/0031-9422(80)83082-2
摘要:Filho RB, Da Silva MS, Gottlieb OR. Flavonoids from Iryanthera laevis. Phytochemistry. 1980 Jan;19(6):1195–7. doi: 10.1016/0031-9422(80)83082-2.
参考文献:10.1016/s0031-9422(00)80162-4
摘要:Vieira PC, Gottlieb OR, Gottlieb HE. Tocotrienols from Iryanthera grandis. Phytochemistry. 1983 Jan;22(10):2281–6. doi: 10.1016/s0031-9422(00)80162-4.
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