专利号:US-6281245-B1 优先权日:1996-10-28 标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof 发明人:PATEL DINESH V; NGU KHEHYONG 权利人:VERSICOR INC 摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteinases).
专利号:US-6541276-B2 优先权日:1996-10-28 标题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof 发明人:PATEL DINESH V; NGU KHEHYONG 权利人:VERSICOR INC 摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).
专利号:CN-1081180-A 优先权日:1992-07-10 标题:Synthesis of Hydrazine Hydrate by Catalyzed Oxidation of Ammonia Sodium Hypochlorite
专利号:US-5252309-A 优先权日:1991-06-12 标 题 :Azine synthesis in the absence of CO2 发明人:KREMPF GERARD; COLLIER BERTRAND; TELLIER PIERRE; SCHIRMANN JEAN-PIERRE 权利人:ATOCHEM ELF SA 摘要:Azines, well suited for hydrolysis into hydrazine, are prepared in high yields by reacting ammonia, aqueous hydrogen peroxide and a carbonyl compound reactant in the presence of a catalytically effective amount of a catalyst medium therefor, i.e., an aqueous solution of ammonium acetate and acetamide or of acetamide and acetic acid, but in the absence of CO 2 .
专利号:US-2001053555-A1 优先权日:1996-10-28 标题 :Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
专利号:CN-101234996-B 优先权日:2008-02-29 标题:A kind of green synthesis method of ketazine