CAS: 56341-41-4; 5-Fluoroindolin-2-One

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1-羟基-3H-吲哚-2-酮置于二乙胺基三氟化硫体系中,用 二氯甲烷 作为反应溶剂,化学反应 0.08H,以81%的收率获得产物5-氟吲哚-2-酮
参考文献:N-芳基-N-羟基酰胺与三乙二硫氨基硫醚(dast)的区域选择性芳族氟化反应
标题:N-芳基-N-羟基酰胺与三乙二硫氨基硫醚(dast)的区域选择性芳族氟化反应
摘要:在常规反应条件下用二乙基氨基三氟化硫(dast)处理n-芳基-N-羟基酰胺可高产率地除去羟基官能团并在芳环对位引入氟原子.
DOI:10.1039/c39920000921

专利信息

专利号:US-2006009510-A1
优先权日:2004-07-09
标 题 :Method of synthesizing indolinone compounds
发明人：HAVENS JEFFREY L; VAIDYANATHAN RAJAPPA
权利人:PHARMACIA & UPJOHN CO LLC
摘要:Disclosed are methods of preparing pyrrole compounds of formula 14 and indolinone compounds of formula 1 n nvia a synthetic route wherein the amide sidechain on the pyrrole moiety is attached prior to pyrrole formation. The compounds 14 produced by the methods herein are useful in the synthesis of compounds of formula 1, which are useful in the treatment of abnormal cell growth, such as cancer.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-10077255-B2
优先权日:2010-04-06
标题:Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones

专利号:US-8563749-B2
优先权日:2010-05-10
标 题:Process for preparing substituted 1,3-dihydro-2H-indol-2-ones
发明人：SIEGEL KONRAD; KARIG GUNTER
权利人:SIEGEL KONRAD; KARIG GUNTER; BAYER CROPSCIENCE AG
摘要:Process for preparing 1,3-dihydro-2H-indol-2-ones, starting from thioalkyl-, or thiocycloalkyl-substituted indol-2-one compounds, involvingn a) dissolving or suspending the thioalkyl-, or thiocycloalkyl-substituted indol-2-one compounds in a polar solvent, b) adding a sulfur-containing salt to the solution or suspension, and c) heating the reaction mixture under reflux at a temperature which corresponds at most to the boiling temperature of the solvent. nn Use of the inventively prepared 1,3-dihydro-2H-indol-2-one as intermediates for the synthesis of fine chemicals and active ingredients from pharmacy and/or agriculture.

专利号:US-6514981-B1
优先权日:1998-04-02
标题:Methods of modulating tyrosine protein kinase function with indolinone compounds
发明人：TANG PENG CHO; SUN LI
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:WO-2011123947-A1
优先权日:2010-04-06
标 题:Synthesis of chiral 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'- indolin]-2'-ones