CAS: 5241-58-7; (S)-2-Amino-3-Phenylpropanamide

上下游产品

CAS号7524-50-7 L-苯丙氨酸甲酯盐酸盐 | CAS号5241-56-5 N-苄氧羰基-D-苯丙氨酰胺 | CAS号65864-22-4 L-苯丙氨酰胺盐酸盐 | CAS号3010-05-7 2-(苄基氨基)乙腈 | CAS号63-91-2 L-苯丙氨酸 | CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号543-27-1 氯甲酸异丁酯 | CAS号2577-90-4 (S)-2-氨基-3-苯基丙酸甲酯 | CAS号47091-50-9 Asp-Phe-NH2 | CAS号145232-34-4 3-环己基-l-丙胺酸酰胺 | CAS号85612-59-5 (2R)-3-苯基丙烷-1,2-二胺 | CAS号65864-22-4 L-苯丙氨酰胺盐酸盐 | CAS号64190-70-1 Phe-Met-Arg-Phe,酰胺 | CAS号5534-95-2 五肽胃泌素 | CAS号13171-96-5 Z-Leu-Phe-NH2 | CAS号129095-62-1 [(1R)-2-氨基-1-苄基... | CAS号5513-69-9 N-[(苯基甲氧基)羰基]甘氨... | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号1142-20-7 |N|-苄氧羰基-L-丙氨酸

L-苯丙氨酸甲酯置于ammonium Hydroxide体系中,用 甲苯 作为反应溶剂,化学反应 16.0H,以79%的收率获得产物l-苯丙氨酰胺
参考文献:芳香族氨基酸酰胺的合成
标题:芳香族氨基酸酰胺的合成
摘要:摘要 芳族氨基酯在甲苯或水中与氢氧化铵水溶液反应,得到中等至高产率的相应酰胺.
DOI:10.1080/00397919608003803

专利信息

专利号:US-3846399-A
优先权日:1969-04-10
标题:Process for controlled stepwise synthesis of polypeptides
发明人：HIRSCHMANN R; DENKEWALTER R
权利人:MERCK & CO INC
摘要:The invention disclosed herein relates to a novel process for the controlled, stepwise synthesis of polypeptides and proteins. More particularly, it is concerned with a process for the rapid and efficient preparation of polypeptides in which multiple sequential steps are carried out without isolation of intermediate peptides. This process for the controlled stepwise synthesis of polypeptides involves reacting a starting amino acid or peptide (or derivative thereof) with an N-carboxy amino acid anhydride (or derivative thereof) in an aqueous medium under conditions of controlled pH such that the only amino group present in appreciable concentration in reactive form during the course of the reaction is the amino group in the starting amino acid or peptide.

专利号:US-12018094-B2
优先权日:2018-04-02
标 题 :Crystalline dipeptides useful in the synthesis of elamipretide
发明人：DUNCAN SCOTT M; REDMON MARTIN P
权利人:STEALTH BIOTHERAPEUTICS INC
摘要:Disclosed are crystalline forms of L-Lys(Boc)-Phe-NH2 and Boc-D-Arg-DMT. The crystalline forms may be used in the synthesis of elamipretide.

专利号:US-9126896-B2
优先权日:2012-06-01
标题:Synthesis of diamido gellants by using Dane salts of amino acids
发明人：BINDL MARTIN; HERRMANN ROLAND; KNAUP GUNTER
权利人:EVONIK INDUSTRIES AG
摘要:The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a Dane salt according to formula II and a Dane salt according to formula III with a coupling reagent; b) adding a diamine according to formula IV to the reaction mixture; and c) adding an acid to the reaction mixture to adjust the pH value of the reaction to <7; wherein L represents a C 2 -C 20 alkyl group, a C 6 -C 20 aryl group, or a C 7 -C 20 alkylaryl group; R 1 and R 2 can be identical or different and represent a hydrogen atom, a C 1 -C 4 alkyl group, a C 1 -C 4 hydroxyalkyl group, a C 1 -C 4 thioether group, a C 6 -C 20 aryl group, a C 7 -C 20 alkylaryl group, a C 7 -C 20 alkylhydroxyaryl group, a C 4 -C 20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C 1 -C 4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C 1 -C 6 alkyl group or a C 7 -C 20 alkylaryl group; R 3 represents a C 1 -C 4 alkyl group; R 4 represents a hydrogen atom, or a C 1 -C 4 alkyl group; R 5 represents a C 1 -C 4 alkyl group; and X represents an alkali metal.

专利号:EP-1960423-B1
优先权日:2004-12-30
标 题:Synthesis of peptide t-20 using peptide intermediate fragments
发明人：HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N
权利人:HOFFMANN LA ROCHE
摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-9475757-B2
优先权日:2013-05-03
标 题 :Synthesis of anti-Parkinson agent
发明人：MUTHUKRISHNAN MURUGAN; MUJAHID MOHAMMAD
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R 1 and R 2 are each independently selected from hydrogen or halogen.

专利号:US-4769445-A
优先权日:1985-03-04
标 题:Process for the solid phase synthesis of peptides which contain sulfated tyrosine
发明人：COMSTOCK JEANNE; ROSAMOND JAMES D
权利人:PENNWALT CORP
摘要:Peptides and Peptide amides such as cholecystokinin (CCK-8) are synthesized in improved yields and purity by a solid phase process. The requisite protected peptide is elaborated and sulfated on a solid support, deprotected, and cleaved from the solid support to give the total synthesis of CCK-8 on a solid support. Thereafter, the peptide is purified in a single step by ion exchange chromatography to provide analytically pure CCK-8.