CAS: 500-05-0; 2-Oxo-2H-Pyran-5-Carboxylic Acid

上下游产品

CAS号617-48-1 DL-苹果酸 | CAS号97-67-6 L-苹果酸 | CAS号7664-93-9 硫酸 | CAS号114106-77-3 dimethyl 4-(met... | CAS号10035-10-6 氢溴酸 | CAS号5435-44-9 N-(1-ethoxycarb... | CAS号3575-31-3 4-辛基苯甲酸 | CAS号31719-76-3 4-苯氧基甲基苯甲酸 | CAS号504-31-4 α-吡喃酮 | CAS号5807-38-5 6-oxo-tetrahydr... | CAS号18069-17-5 2-甲基戊二酸 | CAS号19978-33-7 5-溴-2H-吡喃-2-酮 | CAS号19978-41-7 3,5-二溴-2H-吡喃-2-酮 | CAS号23090-18-8 2-OXO-2H-PYRAN-... | CAS号123-73-9 2-丁烯醛

L-苹果酸置于三氟甲磺酸体系中,用 1,2-二氯乙烷 作为反应溶剂,以86%的收率获得产物香豆酸
参考文献:Upgrading Malic Acid To Bio-Based Benzoates Via A Diels-alder-Initiated Sequence With The Methyl Coumalate Platform
标题:Upgrading Malic Acid To Bio-Based Benzoates Via A Diels-alder-Initiated Sequence With The Methyl Coumalate Platform
摘要:苹果酸二聚体化学反应被优化为从中制备甲基香豆酸酯,通过迪尔斯-阿尔德反应策略产生各种生物基苯甲酸酯.
DOI:10.1039/c4Ra07105K

专利信息

专利号:US-9000209-B2
优先权日:2011-07-22
标题:Method of regioselective synthesis of substituted benzoates
发明人：KRAUS GEORGE A
权利人:KRAUS GEORGE A; UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

专利号:US-9617236-B2
优先权日:2013-05-22
标 题 :Synthesis of coumalic acid
发明人：KRAUS GEORGE A
权利人:UNIV IOWA STATE RES FOUND INC
摘要:A method to prepare coumalic acid comprising (a) heating a solution in dichloroethane of malic acid and sulfuric acid or a solution in dichloroethane of malic acid and a perfluorosulfonic acid or (b) adding an acid comprising sulfuric acid or a perfluorosulfonic acid to a solution of malic acid in dichloroethane to yield a solution that is heated for a period of time so as to convert the malic acid into a major amount of coumalic acid and, optionally, a minor amount of fumaric acid.

专利号:US-8871966-B2
优先权日:2013-03-15
标 题 :Regiospecific synthesis of terephthalates
发明人：KRAUS GEORGE A; LEE JENNIFER J
权利人:KRAUS GEORGE A; LEE JENNIFER J; UNIV IOWA STATE RES FOUND INC
摘要:A method for preparing 1,4-biscarboxylic acid esters of benzene is provided.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-2006252906-A1
优先权日:2003-02-20
标题:Method of synthesis of polyarylenes and the polyarylenes made by such method

专利号:US-2014275608-A1
优先权日:2013-03-15
标题:Of regiospecific synthesis of terephthalates