CAS: 490-53-9; (+-)-6,7-Dimethoxy-1,2-Dimethyl-1,2,3,4-Tetrahydro-Isochinolin

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      专利号:US-9902699-B2
      优先权日:2012-10-24
      标题 :Synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indenes
      发明人：ROSOCHA GREGORY; BATEY ROBERT
      权利人:ROSOCHA GREGORY; Gregory Rosocha
      摘要:A procedure for the synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indene is described. The process involves the use of osmium tetroxide to cleave the indene double bond forming the keto aldehyde product, which is then combined with a substituted amine forming the substituted isoquinoline. Isoquinolines can be useful as industrial products in the chemical, agrochemical, oil and gas industry, as well as useful as medicaments in the pharmaceutical industry.

      专利号:CA-2889118-A1
      优先权日:2012-10-24
      标题 :The synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indenes

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      1: Li X, Leonori D, Sheikh NS, Coldham I. Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine. Chemistry. 2013 Jun 10;19(24):7724-30. doi: 10.1002/chem.201301096. Epub 2013 May 15. 43(10):953-957. doi: 10.1016/s0022-1910(97)00038-3. 104(7):1035-8. doi: 10.1590/s0074-02762009000700017. 75(16):5721-4. doi: 10.1021/jo100714y. 33(1):147-52. doi: 10.1021/jm00163a025. 58(7-8):477-80. doi: 10.1515/znc-2003-7-805. 20(8):1893-906. doi: 10.1007/BF02066231. 64(1):53-62. doi: 10.1002/jps.2600640110. 67(4):473-7. doi: 10.1002/jps.2600670408. 39(4):197-203.

      合成参考文献


      参考文献:10.1590/s0074-02762009000700017
      摘要:Mezghani-Jarraya R, Hammami H, Ayadi A, Damak M. Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula. Mem Inst Oswaldo Cruz. 2009 Nov;104(7):1035–8. doi: 10.1590/s0074-02762009000700017.
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