Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于lithium Aluminium Tetrahydride,乙醚体系中,化学反应生成 三甲基-1,3-丙二胺 参考文献:Antispasmodics. I. Basic Amides Of Benzilic Acid 标题:Antispasmodics. I. Basic Amides Of Benzilic Acid 摘要: DOI:10.1021/ja01618A060
专利号:WO-2016005407-A1 优先权日:2014-07-07 标 题:One-pot synthesis of squaramides 发明人:MÃ?RQUEZ LÓPEZ MARÃ?A EUGENIA; ALEGRE REQUENA JUAN VICENTE; PÉREZ HERRERA RAQUEL 权利人:UNIV ZARAGOZA; CONSEJO SUPERIOR INVESTIGACION 摘要:The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time consuming purification steps, reduces costs and provides better yields as compared with those squaramides obtained through the traditional 'stop-and-go' approach. Moreover, the authors of the present invention herein demonstrate the efficiency of this one-pot process with the synthesis of three biologically active structures, improving in most of the cases the results of the previous stepwise syntheses.
专利号:US-9688644-B2 优先权日:2009-04-30 标 题 :Synthesis of Tetracyclines and intermediates thereto 发明人:MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M 权利人:HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.
专利号:US-4348536-A 优先权日:1975-05-28 标 题 :Odorless catalysts for the synthesis of polyurethanes 发明人:BLAHAK JOHANNES; HUEBNER HANS; KOSTER JOHANNES; MEINERS HANS J; THOMAS HEINZ 权利人:BAYER AG 摘要:The instant invention is directed to novel compounds and the use thereof in producing polyurethane resins. The compounds generally correspond to the following formula: wherein n is an integer of from 1 to 5, R is a C1-C5 alkyl group Y is a C1-C5 alkyl group or a and Z is a where n=0 or 1, X is -O- or and R' is an aliphatic group having from 1 to 15 carbon atoms and may contain ester, ether, or amide groups or tertiary nitrogen and, when m=0, R' may be a hydrogen atom.
专利号:US-2013102730-A1 优先权日:2010-04-02 标 题:Polyamine-containing polymers and methods of synthesis and use 发明人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN 权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES 摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).
专利号:US-2024299311-A1 优先权日:2022-04-05 标题 :Ionizable cationic lipids and lipid nanoparticles 发明人:KARMALI PRIYA PRAKASH; TANIS STEVEN 权利人:KARMALI PRIYA PRAKASH; TANIS STEVEN; CAPSTAN THERAPEUTICS INC 摘要:Ionizable cationic lipids, methods for synthesizing them, as well as intermediates useful in synthesis of these lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is a LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.
专利号:US-7468375-B2 优先权日:2004-04-26 标题:Inhibitors of the HIV integrase enzyme 发明人:DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU 权利人:PFIZER 摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.
[参考文献]: B Lui, Et Al. Radioactive Iodine Exchange Reaction Of Hipdm: Kinetics And Mechanism. J Nucl Med. 1987 Mar;28(3):360-5.
合成参考文献
摘要:Beingessner, R. L.; Longstreet, A. R.; McTeague, T. A.; Kelly, L. P.; Seo, H.; Tran, T. H.; Wicker, A. C.; Jamison, T. F., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 433.