CAS: 3921-01-5; 2,4-Dibromopyrimidine

相似化合物

36847-11-7 1187931-22-1 36847-10-6

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CAS号4595-60-2 2-溴嘧啶 | CAS号66-22-8 尿嘧啶 | CAS号3934-20-1 2,4-二氯嘧啶 | CAS号25095-48-1 2,4-diphenylpyr...

专利信息

专利号:US-2024335420-A1
优先权日:2021-08-02
标题:N-acylhydrazone compounds capable of inhibiting nav 1.7 and/or nav 1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-Acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein substituents R1 to R4 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, useful in the fields of medicinal chemistry, organic synthesis, as well as in the treatment of pain-related disorders.

专利号:US-10870626-B2
优先权日:2014-09-26
标题:Process for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds
发明人：GOSSELIN FRANCIS; HAN CHONG; IDING HANS; REENTS REINHARD; SAVAGE SCOTT; WIRZ BEAT
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.

专利号:EP-3626710-B1
优先权日:2014-09-26
标 题 :Process for preparing an intermediate in the synthesis of (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds

专利号:CN-114057655-B
优先权日:2021-12-13
标 题 :A kind of synthesis method of dibromo compound