📜Orientin-2''-O-Galactopyranoside置于盐酸,水体系中,化学反应 4.0H,反应生成荭草苷 参考文献:Controlled Acid Hydrolysis And Kinetics Of Flavone C-Glycosides From Trollflowers 标题:Controlled Acid Hydrolysis And Kinetics Of Flavone C-Glycosides From Trollflowers 摘要:Acid Hydrolysis Mechanisms Of Orientin-2 ''-O-Galactopyranoside (Oga),Orientin And Other Flavone C-Glycosides In The Trollflowers (Trollius Chinensis Bunge) Were Studied In This Report For The First Time. Hydrolysis Parameters Including Temperature,Acidity,Solvent And Reaction Time Were Comprehensively Investigated. Oga Could Be Hydrolyzed To Orientin,Followed By An Isomerization To Isoorientin Via A Reversible Wessely-Moser Rearrangement Reaction Under Stronger Acidic Conditions. A First-Order Kinetic Model Fitted The Hydrolysis Process Of Oga Well. Under The Optimal Hydrolysis Conditions Of 80 Degrees C,1.0 Mol/l H+ And 7 H Reaction Time,About 77% Oga Was Transformed To Orientin With No Detectable Isoorientin. These Results Could Be Helpful For Better Understanding Of The Acid Hydrolysis Kinetics Of Flavone C-Glycosides,As Well As The Preparation Of These Valuable Components Under Controlled Acid Hydrolysis Conditions. (C) 2014 Jiang-Yun Liu. Published By Elsevier B.V. On Behalf Of Chinese Chemical Society And Institute Of Materia Medica,Chinese Academy Of Medical Sciences. All Rights Reserved. Doi:10.1016/j.Cclet.2014.11.021
专利号:WO-2025081225-A1 优先权日:2023-10-17 标 题 :Synthesis of polyphenols 发明人:TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT 权利人:Delica Therapeutics Pty Ltd 摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.
专利号:US-2021315830-A1 优先权日:2018-08-31 标题 :A curcumin loaded stabilized polymeric nanoparticles with increased solubility and photo-stability and a green process for the synthesis thereof 发明人:ACHARYA AMITABHA; KUMARI AVNESH; GULIANI ANIKA; KUMAR SANJAY 权利人:COUNCIL SCIENT IND RES 摘要:The present invention explored PLGA NPs synthesis using plant extracts as surfactants by nanoprecipitation process. PLGA NPs synthesized using Camellia sinensis, Dendrocalamus hamiltonii, Ficus palmata and Rubus ellipticus leaf extracts were further explored for encapsulation, controlled and sustained release of well-known antioxidant molecule, curcumin. This plant extract based nanoprecipitation process for the synthesis of PLGA NPs can be further explored for encapsulation of many other antioxidant molecules of therapeutic importance.
专利号:US-2006115880-A1 优先权日:2002-12-03 标 题 :Enzymatic production of acyl flavonoid derivatives 发明人:GHOUL MOHAMED; ENGASSER JEAN-MARC; MOUSSOU PHILIPPE; PAULY GILLES; ARDHAOUI MELIKA; FALCIMAIGNE AUDE 权利人:COGNIS FRANCE SA 摘要:Disclosed is a method for enzymatic synthesis of esters of flavonoid and flavonoid derivatives, according to which a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycon flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are separated from the enzymatic particles and the solvent. The inventive method is characterized by maintaining the concentration of water and/or alcohol which are formed during the reaction to below 150 mM. Advantageously, the molar ratio of flavonoid to acyl donor in the reaction medium is maintained in the range from 0.01 to 20.00 during the reaction.
专利号:US-2024026314-A1 优先权日:2020-11-25 标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds 发明人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.
专利号:US-2008233242-A1 优先权日:2003-10-08 标 题:Antioxidant of Bamboo Leaves and Its Uses 发明人:ZHANG YING; WU XIAOQIN; YU ZHUOYU; LUO DINGDING; LU BOYI; ZHANG YU 权利人:ZHANG YING; WU XIAOQIN; YU ZHUOYU; LUO DINGDING; LU BOYI; ZHANG YU 摘要:The present invention discloses the composition of antioxidant of bamboo leaves (AOB) and its use. The purpose of present invention is to provide a new food additive which is natural, nutritional, and muti-functional, and which is of rich resources, safety, good effect, and low cost. AOB is yellow or brown powders or particles obtained from bamboo leaves, wherein the main antioxidative components include flavones, lactones, phenolic acids. AOB can either inhibit lipid autoxidation chain reaction, or chelate transitional metal ions, and can be used as primary and second antioxidant. AOB can eliminate nitrite and inhibit the synthesis of N-nitrosamine, and has anti-bacteria, bacteriostatic, deodorizing, aroma enhancing etc. functions. AOB can be commonly used in oil-containing food, meat product, fishery product, expanded food etc. food systems.
专利号:US-12194020-B2 优先权日:2017-12-22 标 题:Reversing baldness through cannabinoid receptor activation 发明人:POSTREL RICHARD 权利人:POSTREL RICHARD 摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.
1: Zhao N, Sun Q, Song Y, Wang L, Zhang T, Meng F. Comparative pharmacokinetics study of orientin in rat plasma by UHPLC-MS/MS after intravenous administration of single orientin and Trollius chinensis Bunge extract. Biomed Chromatogr. 2018 Apr;32(4). doi: 10.1002/bmc.4142. Epub 2017 Dec 26. doi: 10.1016/j.jstrokecerebrovasdis.2017.05.002. Epub 2017 Jun 20. doi: 10.1177/1535370217737983. Epub 2017 Oct 26. 4: Bae JS. Inhibitory Effect of Orientin on Secretory Group IIA Phospholipase A2. Inflammation. 2015 Aug;38(4):1631-8. doi: 10.1007/s10753-015-0139-8. doi: 10.1016/j.biopha.2017.11.088. Epub 2017 Dec 2. doi: 10.1038/s41598-018-23419-x. 7: Wang S, Yu Y, Feng Y, Zou F, Zhang X, Huang J, Zhang Y, Zheng X, Huang XF, Zhu Y, Liu Y. Protective effect of the orientin on noise-induced cognitive impairments in mice. Behav Brain Res. 2016 Jan 1;296:290-300. doi: 10.1016/j.bbr.2015.09.024. Epub 2015 Sep 21. doi: 10.1002/mnfr.201400753. Epub 2015 Apr 29. Erratum in: Mol Nutr Food Res. 2015 Jul;59(7):1411.
合成参考文献
参考文献:10.1248/bpb.29.1271 摘要:Shimamura N, Miyase T, Umehara K, Warashina T, Fujii S. Phytoestrogens from Aspalathus linearis. Biological & Pharmaceutical Bulletin. 2006;29(6):1271–4. doi: 10.1248/bpb.29.1271.