CAS: 26575-93-9; (1S,3R)-1-((R)-3,3-Dimethyloxiran-2-yl)-3-((5R,8S,9S,10S,11S,14R)-11-Hydroxy-4,4,8,10,14-Pentamethyl-3,16-Dioxo-2,3,4,5,6,7,8,9,10,11,12,14,15,16-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Butyl Acetate
该化合物是一种来自自然来源的三叶类化合物,主要是Alsma orentale 的硫化物,其特点是C-23位置的乙酰结构增强了其稳定性和生物活性,该化合物具有显著的药理特性,包括抗炎,肝脏保护和脂质减低效应,使它成为医药化学和药物开发的热点,其行动机制往往涉及代谢途径的调节,例如与胆固醇合成有关的路径.Alisol C 23-乙酸盐通常用于研究环境,研究三叶类生物化学和潜在的治疗应用.高纯度等级可用于分析和实验用途.
- 英文名称(1S,3R)-1-((R)-3,3-Dimethyloxiran-2-yl)-3-((5R,8S,9S,10S,11S,14R)-11-Hydroxy-4,4,8,10,14-Pentamethyl-3,16-Dioxo-2,3,4,5,6,7,8,9,10,11,12,14,15,16-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Butyl Acetate
- 中文名称泽泻醇C单乙酸脂
- IUPAC名称(1S,3R)-1-((R)-3,3-dimethyloxiran-2-yl)-3-((5R,8S,9S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3,16-dioxo-2,3,4,5,6,7,8,9,10,11,12,14,15,16-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)butyl acetate
- 其它别名23-O-Acetylalisol C; Alisol C Monoacetate
- CAS编号26575-93-9
- MFCD编号:MFCD23379923
- FDA UNII编号:TF3DV2XK24
- 分子式:C32H48O6分子量:528.73
- 产品CID: 1243484
- 产品分类生物化工 → 提取物 → 植物提取物
物理性质
- 沸点624.9±55.0 °C(预测)
- 密度1.15
- pKa:14.36±0.70(预测)
- PSA:93.2
- LogP:5.5899
- 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
- 外观形态白色粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物用作内容确定,识别和药理研究;药理学上,它减少了血清总胆固醇和三重液化水平,减缓了神乐硬化的进化;ALISOR C-23 EETATE的现代应用及其相关配方包括内分泌性脊椎炎,糖尿病,精液性贫血,精子性肝病和糖尿病的治疗.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Jia X, Zhu H, Li G, Lan M, Li X, Huang M, Xu W, Wu S. Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition. Biomed Pharmacother. 2021 May;137:111321. doi: 10.1016/j.biopha.2021.111321. Epub 2021 Jan 29. 26(9-10):491-511. doi: 10.1007/s10495-021-01684-y. Epub 2021 Jul 16.
80:347-360. doi: 10.1016/j.bioorg.2018.07.001. Epub 2018 Jul 2. 64(Pt 11):o2231. doi: 10.1107/S1600536808032959.
5: Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY, Woo JT. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 2010 Aug 1;80(3):352-61. doi: 10.1016/j.bcp.2010.04.014. Epub 2010 Apr 20.
合成参考文献
参考文献:10.1016/j.ejmech.2019.111652
摘要:Luan ZL, Huo XK, Dong PP, Tian XG, Sun CP, Lv X, Feng L, Ning J, Wang C, Zhang BJ, Ma XC. Highly potent non-steroidal FXR agonists protostane-type triterpenoids: Structure-activity relationship and mechanism. Eur J Med Chem. 2019 Nov 15;182():111652. doi: 10.1016/j.ejmech.2019.111652.
参考文献:10.1371/journal.pone.0240616
摘要:Xu X, Li L, Zhang Y, Lu X, Lin W, Wu S, Qin X, Xu R, Lin W. Hypolipidemic effect of Alisma orientale (Sam.) Juzep on gut microecology and liver transcriptome in diabetic rats. PLoS ONE. 2020 Oct 09;15(10):e0240616. doi: 10.1371/journal.pone.0240616.
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