CAS: 22419-35-8; 4,4-Difluorocyclohexanol

相似化合物

22515-18-0 1067230-56-1 74058-19-8

4-苯甲酰基氧基环己醇置于二乙胺基三氟化硫,水,Pyridinium Chlorochromate,Potassium Hydroxide体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成4,4-二氟环己醇
参考文献:Discovery Of Bacterial Nad+-Dependent Dna Ligase Inhibitors: Improvements In Clearance Of Adenosine Series
标题:Discovery Of Bacterial Nad+-Dependent Dna Ligase Inhibitors: Improvements In Clearance Of Adenosine Series
摘要:Optimization Of Clearance Of Adenosine Inhibitors Of Bacterial Nad(+)-Dependent Dna Ligase Is Discussed. To Reduce Cytochrome P-450-Mediated Metabolic Clearance,Many Strategies Were Explored; However,Most Modifications Resulted In Compounds With Reduced Antibacterial Activity And/or Unchanged Total Clearance. The Alkyl Side Chains Of The 2-Cycloalkoxyadenosines Were Fluorinated,And Compounds With Moderate Antibacterial Activity And Favorable Pharmacokinetic Properties In Rat And Dog Were Identified. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.11.071

专利信息

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优先权日:2020-07-02
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专利号:US-2023286904-A1
优先权日:2020-07-02
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