CAS: 1950-85-2; Sodium Methanesulfonothioate

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CAS号20277-69-4 甲烷亚磺酸钠 | CAS号124-63-0 甲基磺酰氯 | CAS号2386-57-4 甲基磺酸钠 | CAS号56-00-8 1,5-戊二基双甲硫代磺酸盐 | CAS号3948-46-7 α,α'-对二甲苯基双甲硫代磺酸盐 | CAS号92953-12-3 2-Carboxyethyl ... | CAS号190852-41-6 2-methylsulfony... | CAS号2043-76-7 甲基硫代磺酸乙酯 | CAS号7559-62-8 甲硫基苄基磺酸盐 | CAS号55-99-2 1,4-丁二基双甲硫代磺酸盐 | CAS号13700-08-8 2-Hydroxyethyl ...

📜Methanesulfonic Acid Sodium Salt置于硫化氢体系中,用 甲醇 用作溶剂,化学反应生成硫甲磺酸钠
参考文献:Coating Surfaces
标题:Coating Surfaces
摘要:公开了一种间接地将特定结合对(或sbp)的成员附着到表面的方法,该方法包括以下步骤:(a)将表面与具有侧链的聚合物的溶液接触,该侧链符合以下公式x-Y-Z-R,其中x是一个空间群;Y是硫,硒或碲原子;Z是硫,硒或碲原子,其中任何一个可能与一个或两个氧原子结合;其中r是任何适当的基团,使得-Z-R构成一个脱离基团;使得至少一些-Z-R基团被取代,聚合物通过x-Y基团结合到表面;和(b)将步骤(a)得到的涂有聚合物的表面与包含sbp成员的溶液接触,从而使聚合物与sbp成员发生反应,将sbp成员间接地附着到表面.

专利信息

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

专利号:US-6627744-B2
优先权日:1999-07-02
标 题 :Synthesis of glycodendrimer reagents
发明人：DAVIS BENJAMIN G; JONES JOHN BRYAN; BOTT RICHARD R
权利人:GENENCOR INT
摘要:The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.

专利号:US-2018222936-A1
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids

专利号:CA-2842358-A1
优先权日:2011-07-19
标题 :Methods for the synthesis of functionalized nucleic acids

专利号:JP-6128529-B2
优先权日:2011-07-19
标题:Methods for the synthesis of functionalized nucleic acids

专利号:CA-2842358-C
优先权日:2011-07-19
标题 :Methods for the synthesis of functionalized nucleic acids