CAS: 16954-69-1; 2-Methylaminobenzethiazole

相似化合物

16349-38-5 4074-74-2 136-95-8

上下游产品

2-thioxo-3H-1,3-benzothiazole methylamine 1-methyl-1-phenylthiourea 1-methyl-3-phenylthioureamethabenzthiazuron benzothiazol-2-yl-methyl-carbamic acid methyl ester N-methyl-6-nitrobenzo[d]thiazol-2-amine N-(benzo[d]thiazol-2-yl)-N-methylbenzamide

📜1-甲基-3-苯基硫脲置于溴,溶剂黄146体系中,化学反应 3.0H,以83%的收率获得2-甲氨基苯并噻唑
参考文献:使用三溴苄基三甲基铵将取代的芳基硫脲有效地转化为2-氨基苯并噻唑.
标题:使用三溴苄基三甲基铵将取代的芳基硫脲有效地转化为2-氨基苯并噻唑.
摘要:已知分子溴(br2)与芳基硫脲反应生成2-氨基苯并噻唑(hugerschoff反应).我们在这里显示了三溴苄基三甲基铵(1,Phch2Nme3Br3),一种稳定的结晶有机三溴化铵(oatb),可以很容易地用作替代的亲电子溴源.用oatb更容易控制添加的化学计量,从而最大程度地减少了由过量试剂引起的芳香族溴化反应.我们已经开发了一种直接程序,该程序可以使用四丁基硫氰酸铵(bu4Nscn)和phch2Nme3Br3从异硫氰酸酯和胺中制备官能化的2-氨基苯并噻唑.
Doi:10.1021/jo0349431

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:RU-1814643-C
优先权日:1987-06-25
标题:Improved method of synthesis of carbamate or urea derivatives

专利号:CN-109338402-A
优先权日:2018-11-29
标题 :A kind of method of electro-catalysis benzo thioamide analog compound synthesis benzothiazole in water

专利号:WO-2010001220-A1
优先权日:2008-07-01
标 题 :New 1,2,4-triazine derivatives and biological applications thereof
发明人：DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA
权利人:MUTABILIS SA; DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA
摘要:The invention relates to new 1,2,4-triazine derivatives of formula (I): wherein A, B, R2 and Y are defined in the application, their preparation and intermediates, their use as drugs and pharmaceutical compositions and associations containing them. The compounds of formula (I) are capable of inhibiting bacterial heptose synthesis.

专利号:CN-109293599-A
优先权日:2018-11-29
标 题:A kind of method of microwave radiation benzo thioamide analog compound synthesis benzothiazole in water phase