CAS: 15837-41-9; 5-Hydroxypyrimidin-4(3H)-One

相似化合物

6623-81-0 6623-81-0 4763-35-3

上下游产品

CAS号91138-06-6 5-(苄氧基)嘧啶-4-醇

📜2-Sulfanyl-5-(Tetrahydro-2H-Pyran-2-Yloxy)Pyrimidin-4(3H)-One置于ammonium Hydroxide,镍体系中,用 水 用作溶剂,化学反应 4.0H,以46%的收率获得5-羟基-4(1H)-嘧啶酮
参考文献:An Autoxidation Study Of C2 Substituted Pyrimidine Amino Reductones
标题:An Autoxidation Study Of C2 Substituted Pyrimidine Amino Reductones
摘要:Three Pyrimidine Derivatives (8A-C),Differing From Isouramil And Divicine At C2,Have Been Synthesized And Their Autoxidation Rates Measured Spectrophotometrically. The Autoxidation Rates Of All Five Pyrimidines (8A-C,Isouramil And Divicine) Were Correlated With Sigma(+)(P) Values (Rho=-1.28,R(2)=0.949). (C) 2006 Published By Elsevier Ltd.
Doi:10.1016/j.Tet.2006.03.049

专利信息

专利号:US-2010008874-A1
优先权日:2006-04-11
标 题:Substituted pyrimidines, process for their production and their use as effective absorbents of uv irradiation
发明人：CLAES ENK DAVID; SREBNIK MORRIS
权利人:YISSUM RES DEV CO
摘要:The present invention discloses substituted pyrimidines, processes for their synthesis and their use as effective sun-protecting agents either alone or in combination with other known sun-protecting agents.

专利号:JP-2000281611-A
优先权日:1999-03-30
标 题 :Synthesis of phenolic compound having protected hydroxy group, and radioactive ray-sensitive composition by using the same

专利号:WO-2017156194-A1
优先权日:2016-03-08
标题:Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
发明人：PUERTA DAVID T; COHEN SETH M; CREDILLE CY V
权利人:UNIV CALIFORNIA; PUERTA DAVID T
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

专利号:US-10889556-B2
优先权日:2016-03-08
标题 :Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease
发明人：COHEN SETH M; CREDILLE CY V; PUERTA DAVID T
权利人:UNIV CALIFORNIA
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

专利号:WO-2021127273-A1
优先权日:2019-12-20
标题:1 -((6-oxo-1,6-dihydropyridazin-4-yl)methyl)piperazine and 1 -((6-oxo-1,6-dihydropyrimidin-4-yl)methyl)piperazine derivatives as prolyl hydroxylase, hif-1 alpha and pgk modulators for use in treating inflammatory diseases, cancer or infections
发明人：COBURN CRAIG; ROWBOTTOM MARTIN W
权利人:GB004 INC
摘要:Described herein are compounds of formulae (I), (lla) and (Mb) as prolyl hydroxylase inhibitors, HIF-lalpha stabilizers and PGK up regulators for use in treating inflammatory diseases, cancer or infections: Preferred compounds are e.g. tert-butyl-4-((l-benzyl-6-oxo-l,6- dihydropyridazin-4-yl)methyl)piperazine-l-carboxylate and tert-butyl-4-((l-benzyl-6-oxo-l,6-dihydropyrimidin-4-y I) methyl) piperazine-l-carboxylate derivatives and related compounds. Exemplary compounds are e.g. compound 1A: and compound 2A: The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 22 to 25 and 55 to 70; examples 1 to 5; compounds 1A to 2V; tables 1 and 2).