CAS: 13612-34-5; 2-(2,5-Dimethylphenyl)Acetic Acid

相似化合物

6972-51-6 30981-98-7 6331-04-0

上下游产品

(2,5-dimethylphenyl)acetonitrile 3,6-dimethyl-cyclohepta-1,3,6-trienecarboxylic acid (2,5-dimethyl-phenyl)-acetic acid amide carbon dioxide 2-(2,5-dimethylphenyl)ethan-1-ol methyl 2-(2,5-dimethylphenyl)acetate -ethylalkohol1,1-Dideutero-2-1-(2,5-dimethyl)-phenyl-ethylalkohol indole3-β-(2',5'-dimethylphenylacetamido)ethylindole

2,5-二甲基苯乙酮置于吗啉,对甲苯磺酸,Sulfur,Sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 13.0H,反应生成2,5-二甲基苯乙酸
参考文献:3-芳基香豆素通过抑制ages的产生和抗氧化应激来抑制血管钙化
标题:3-芳基香豆素通过抑制ages的产生和抗氧化应激来抑制血管钙化
摘要:摘要 客观的 本工作旨在筛选预防和治疗血管钙化的药物.方法:我们使用人主动脉血管平滑肌细胞筛选了一系列用于检测血管钙化相关因子的 3-芳基香豆素. 结果 我们发现化合物14和32在 Ages 诱导的钙化细胞模型中显着抑制碱性磷酸酶 (Alp) 活性,类似于氨基胍盐酸盐 (Agh).我们还发现化合物14和32可以显着降低钙化细胞模型中 Ages,细胞内钙离子和总 Ros 等因子的水平.进一步研究表明,化合物14可显着抑制钙化细胞中 P-Erk1/2,Pkc,Nf-κb,Rage 和 Opn 蛋白的表达,并增加 Sm22-α 和 Ppar-γ 蛋白的表达. 结论 我们推测化合物14通过抑制氧化应激和抑制 Ages 产生来抑制血管钙化,这表明 3-芳基香豆素衍生物是治疗血管钙化的潜在候选者.
Doi:10.1080/14756366.2022.2109024

专利信息

专利号:US-4544450-A
优先权日:1980-07-15
标 题 :Electrochemical process for the synthesis of organic compounds
发明人：OBERRAUCH ERMANNO; EBERSON LENNARD
权利人:ANIC SPA
摘要:An electrochemical process is disclosed for the synthesis of organic compounds, said process having the unique characteristic that the element evolved at the anode is exploited by having it reacting with the product of electrolysis obtained at the cathode by the presence of an appropriate catalyst. The catalyst may be associated in the most convenient manner to the anode, or it can be the anode itself. The process opens the way to a number of synthesis reaction which may be carried out electrolytically instead of the conventional ways.

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK

专利号:US-8664424-B2
优先权日:2011-03-13
标 题:Method for preparing 2,5-dimethylphenylacetic acid
发明人：WANG PING; FAN XIAOBIN; LIN XINGJUN; HE ZHAOHUI
权利人:WANG PING; FAN XIAOBIN; LIN XINGJUN; HE ZHAOHUI; LIANHE CHEMICAL TECHNOLOGY CO LTD; JIANGSU LIANHE CHEMICAL TECHNOLOGY CO LTD
摘要:Provided is a method for preparing 2,5-dimethylphenylacetic acid, wherein p-xylene is mixed with paraformaldehyde and concentrated hydrochloric acid in a solvent of ion liquid to obtain 2,5-dimethyl benzyl chloride by the chloromethylation reaction. Then, 2,5-dimethyl benzyl chloride is introduced into a reactor with an acid binding agent and a solvent, the carbonylation and hydrolysis reaction is conducted in the presence of a catalyst to obtain 2,5-dimethylphenylacetic acid. The present process has new route, less synthesis steps, simple operation, lower cost, increased yield, and is friendly to the environment. Therefore, the method is suitable for industrial production.

专利号:TW-568914-B
优先权日:1996-12-23
标题 :Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:CN-1242007-A
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising such compounds, and methods of inhibiting beta amyloid peptide release and/or its synthesis using such compounds