CAS: 1330-44-5; Aluminum Hydroxide (Al(Oh)3), Hydrate (8Ci,9Ci)

专利信息

专利号:US-6544757-B1
优先权日:1981-08-04
标 题 :Synthesis of human virus antigens by yeast
发明人：RUTTER WILLIAM J; VALENZUELA PABLO D T; HALL BENJAMIN D; AMMERER GUSTAV
权利人:UNIV CALIFORNIA
摘要:The present invention relates to synthesis of HB S Ag in yeast. Yeast expression vectors comprising a yeast promoter, ADH1, have been constructed. The region of the HBV genome coding for the S-protein, excluding a possible 163 amino acid presequence, has been transferred to the yeast expression vector. Using the described yeast vector, the successful synthesis of HB S Ag by yeast has been achieved. The product is antigenic (reactive with anti-HB S Ag), and a substantial portion is found associated with particles identical in electron microscopic appearance to those found in the serum of HBV-infected patients and in Alexander cells but having a smaller particle size diameter. The HB S Ag synthesized by yeast has identical sedimentation behavior to purified, naturally occurring HB S Ag particles purified from Alexander cells as measured by sucrose gradient sedimentation. The present invention demonstrates synthesis and assembly of a higher ordered multi-component structure resulting from expression of a heterologous DNA coding segment in a microorganism.

专利号:EP-0072318-B1
优先权日:1981-08-04
标 题:Synthesis of human virus antigens by yeast
摘要:The present invention relates to synthesis of HBsAg in yeast. Yeast expression vectors comprising a yeast promoter, ADHI, have been constructed. The region of the HBV genome coding for the S-protein, excluding a possible 163 amino acid presequence, has been transferred to the yeast expression vector. Using the described yeast vector, the successful synthesis of HBsAg by yeast has been achieved. The product is antigenic (reactive with anti-HBsAg), and a substantial portion is found associated with particles identical in electron microscopic appearance to those found in the serum of HBV-infected patients and in Alexander cells but having a smaller particle size diameter. The HBsAg synthesized by yeast has identical sedimentation behavior to purified, naturally-occurring HBsAg particles purified from Alexander cells as measured by sucrose gradient sedimentation. The present invention demonstrates synthesis and assembly of a higher ordered multi-component structure resulting from expression of a heterologous DNA coding segment in a microorganism.

专利号:EP-0340806-B1
优先权日:1981-08-04
标 题 :Synthesis of human virus antigens by yeast
发明人：RUTTER WILLIAM J; VALENZUELA PABLO D T; HALL BENJAMIN D; AMMERER GUSTAV
权利人:UNIV CALIFORNIA; WASHINGTON RES FOUND
摘要:The present invention relates to synthesis of HBsAg in yeast. Yeast expression vectors comprising a yeast promoter, ADHl, have been constructed. The region of the HBV genome coding for the S-protein, excluding a possible 163 amino acid presequence, has been transferred to the yeast expression vector. Using the described yeast vector, the successful synthesis of HBsAg by yeast has been achieved. The product is antigenic (reactive with anti-HBsAg) , and a substantial portion is found associated with particles identical in electron microscopic appearance to those found in the serum of HBV-infected patients and in Alexander cells but having a smaller particle size diameter. The HBsAg synthesized by yeast has identical sedimentation behavior to purified, naturally-occurring HBsAg particles purified from Alexander cells as measured by sucrose gradient sedimentation. The present invention demonstrates synthesis and assembly of a higher ordered multi-component structure resulting from expression of a heterologous DNA coding segment in a microorganism.

专利号:US-4598061-A
优先权日:1984-02-02
标 题 :Catalyst for the synthesis of methanol and alcohol mixtures containing higher alcohols and method of making the catalyst
发明人：SCHNEIDER MICHAEL; KOCHLOEFL KAREL; BOCK ORTWIN
权利人:SUED CHEMIE AG
摘要:Catalyst for the synthesis of alcohol mixtures containing methanol and higher aliphatic alcohols from CO and H2, which contains, as an oxide precursor, (a) copper oxide and zinc oxide, which can be transformed into the catalytically active state by reduction with hydrogen; (b) aluminum oxide as a thermostabilizing substance and (c) at least one alkali carbonate or alkali oxide, the oxidic precursor comprising from 20 to 70% of the total volume of pores having a diameter between 14 and 7.5 nm, the alkali content being 13-130x10-6 gram atom alkali metal per gram of the oxidic precursor, and the aluminum oxide component having been obtained from a colloidally dispersed aluminum hydroxide gel or sol.

专利号:US-2006134739-A1
优先权日:2003-03-11
标 题 :Synthesis of proteins by cell-free protein expression
发明人：CHATTERJEE DEB K
权利人:CHATTERJEE DEB K
摘要:In Vitro peptide/protein or biological macromolecule synthesis systems, and methods and kits thereof improve efficiency of in vitro protein or biological macromolecule synthesis and related compositions.

专利号:US-2014234364-A1
优先权日:2011-09-23
标 题:Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis
发明人：SEEBERGER PETER H; YANG YOU; ANISH CHAKKUMKAL; REINHARDT ANIKA
权利人:MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V
摘要:The present invention relates to the total chemical synthesis of the monosaccharide 35 # (R′â•?H), the disaccharide 36 # (R′≠H; R″â•?H), the trisaccharide 37 # (R′≠H; R″≠H; R′″≠H) and the tetrasaccharide 1 # (R′≠H; R″≠H; R′″≠H) of the following general formula wherein R represents —Y—NH 2 Y represents a linker R′ is H or R″ is H or R′″ is H or of the lipopolysaccharide from Neisseria meningitidis , as well as to the trisaccharide 37 # and the tetrasaccharide 1 # , to vaccines containing at least one of the saccharides 1 # , 35 # , 36 # , and 37 # and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α-Hep-( 1→3 )-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or α-GlcNAc-(1→2)-±-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.