CAS: 13057-72-2; 7-Hydroxyisoflavone

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486-66-8 96644-05-2 485-72-3

上下游产品

CAS号3669-41-8 2,4-二羟基苯基苄酮 | CAS号122-51-0 原甲酸三乙酯 | CAS号70-11-1 2-溴苯乙酮 | CAS号95-01-2 2,4-二羟基苯甲醛 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号110-89-4 六氢吡啶 | CAS号79-16-3 N-甲基乙酰胺 | CAS号103-82-2 苯乙酸 | CAS号108-46-3 间苯二酚 | CAS号22877-01-6 1-(2,4-双(苄氧基)苯基)乙酮 | CAS号35212-22-7 依普黄酮 | CAS号574-12-9 异黄酮 | CAS号131814-54-5 (4-oxo-3-phenyl... | CAS号121587-66-4 7-hydroxy-3-phe... | CAS号20594-05-2 6-HYDROXYFLAVON... | CAS号1621-56-3 7-甲氧基异黄酮

依普黄酮置于microsome Containing Human Cdna-Expressed Cyp3A4 Glucose-6-Phosphate Dehydrogenase,α-D-吡喃葡萄糖6-磷酸,烟酰胺腺嘌呤双核苷酸磷酸盐体系中,用 甲醇,Phosphate Buffer 用作溶剂,化学反应 0.33H,反应生成7-羟基异黄酮
参考文献:介导人肝微粒体中异丙基黄酮代谢的细胞色素p450的表征.
标题:介导人肝微粒体中异丙基黄酮代谢的细胞色素p450的表征.
摘要:据报道,用于预防和治疗骨质疏松症的合成类黄酮伊普黄酮在人体中广泛代谢为7种代谢物(m1-M7).进行这项研究的目的是鉴定负责依普黄酮代谢的人肝细胞色素p450(cyp).在三种不同的人肝微粒体制剂中,乙炔异黄酮代谢的主要途径是在β环上羟基化成m3,在o上脱烷基化成m1和在异丙基上氧化成m4和m5.通过相关分析,免疫抑制,人肝微粒体的化学抑制以及表达的重组cyp酶的代谢相结合,鉴定了负责将依普黄酮氧化为活性代谢物m1,M3,M4和m5的特定cyp.依普黄酮及其五种代谢产物的抑制能力 在人肝微粒体中研究了7种具有临床意义的重要cyp的m1-M5.我们的研究结果表明,Cyp3A4在伊普黄酮到m1的o-脱烷基作用中起主要作用,而cyp1A2在m3,M4和m5的形成中起主要作用.发现异黄酮和/或其五种代谢产物有效抑制cyp 1A2,2C8,2C9和2C19底物的代谢.
Doi:10.1080/00498250601146962

专利信息

专利号:US-2009062555-A1
优先权日:2007-08-28
标 题 :Synthesis of Isoflavone
发明人：HARMS ARTHUR E
权利人:HARMS ARTHUR E
摘要:The invention provides a process of manufacturing an isoflavone of the general formula 7 n n n n n n n n n n wherein R 1 , R 2 , R 3 , and R 4 each independently are H, OH, or an alkoxy, provided at least one of R 1 , R 2 , R 3 , and R 4 being OH, and one being alkoxy, or at least 2 groups being OH, comprising providing ketone (3) n n n n n n n n n n wherein R 1 , R 2 , R 3 , and R 4 are as stated above, combining (3) with trialkylortho formate, and a Lewis or Bronsted acid to produce the isoflavone, precipitating the isoflavone.

专利号:CN-102241657-A
优先权日:2011-05-04
标 题:Synthesis of Isoflavones by Stille Cross-Coupling Reaction

专利号:CN-103265518-B
优先权日:2013-05-24
标题:Synthesis of Isoflavones by Photochemical Reaction

专利号:CN-103275052-A
优先权日:2013-05-24
标题 :Synthesis of Isoflavones by Nickel-Catalyzed Negishi Cross-Coupling Reaction at Room Temperature

专利号:CN-103265518-A
优先权日:2013-05-24
标 题:Synthesis of Isoflavones by Photochemical Reaction

专利号:CN-117736169-A
优先权日:2023-12-19
标题:A kind of synthesis method of ipflavone