CAS: 119-36-8; Methyl 2-Hydroxybenzoate

相似化合物

69-72-7 78646-17-0 90-01-7

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CAS号67-56-1 甲醇 | CAS号69-72-7 水杨酸 | CAS号6282-42-4 methyl 2-prop-2... | CAS号606-45-1 2-甲氧基苯甲酸甲酯 | CAS号95-48-7 邻甲酚 | CAS号30414-57-4 3-Oxo-6-hepteno... | CAS号27701-23-1 methyl 2-(metho... | CAS号118-61-6 水杨酸乙酯 | CAS号82091-12-1 methyl 2-(2-met... | CAS号74-88-4 碘甲烷 | CAS号110284-90-7 methyl 2-(4,6-d... | CAS号112211-79-7 methyl 2-(2-for... | CAS号606-45-1 2-甲氧基苯甲酸甲酯 | CAS号4068-78-4 5-氯水杨酸甲酯 | CAS号7606-87-3 3,5-Dichloro-2-... | CAS号551-35-9 N-异丙基水杨酰胺 | CAS号607-90-9 水杨酸丙酯 | CAS号52803-70-0 2-(2-氯苄氧基)-苯甲酸 | CAS号39732-01-9 2-呋喃-2-苯甲酸甲酯 | CAS号35700-40-4 2,3-二氢苯并呋喃-7-羧酸

苯甲酸甲酯置于oxone,Ru(P-Cymene)(Dibrbpy)(Mesco2),三氟乙酸,三氟乙酸酐体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 8.0H,以73%的收率获得水杨酸甲酯
参考文献:联吡啶钌催化剂的设计与合成:一种低成本实现芳烃和杂芳烃羟基化的方法
标题:联吡啶钌催化剂的设计与合成:一种低成本实现芳烃和杂芳烃羟基化的方法
摘要:设计并合成了两种新的钌联吡啶复合物用于分子间csp 2-H羟基化.采用一种环境友好的廉价氧化剂作为氧源,从而提高了其适用性,并显着提高了收率.在催化过程中,形成了钌(iv)阳离子络合物,该络合物能够形成区域选择性的c O键,并且被证明对宽泛的底物范围具有耐受性.已经有效地研究了与可移动和不可移动的导向基团相邻的c H键的活化.
Doi:10.1016/j.Tetlet.2017.08.037

专利信息

专利号:US-6815214-B2
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of diketopiperazines
发明人：BOYCE JIM P; HOWBERT J JEFFRY; TABONE JOHN C
权利人:CELLTECH R & D INC
摘要:The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-α, TNF-β and also apoptosis.

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-7173021-B2
优先权日:2004-09-02
标题:Synthesis of temozolomide esters as potent anticancer pro-drugs for topical and transdermal applications in treatments of cancers
发明人：WANG YONGFENG; CONWAY BARBARA R; SUPPASANSATORN PANASSAYA
权利人:TIANJIN NORTH PHARM SCI TECH C
摘要:This invention relates to the use of temozolomide esters (4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylate esters) Formula 1 as potent anticancer pro-drugs for treatment of cancers by topical and transdermal applications, and to a novel process for synthesis of temozolomide esters by a direct esterification of temozolomide acid (3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid) with a halogeno-aliphatic compound in presence of a base, or with an alcohol in presence of a dehydrate agent

专利号:WO-2006046949-A1
优先权日:2004-10-22
标 题 :SYNTHESIS AND ANTIMALARIAL ACTIVITY OF PYRROLO[3,2-f]QUINAZOLINE-1,3- DIAMINE DERIVATIVES
发明人：AI J LIN; JIAN GUAN; QUAN ZHANG; SKILLMAN DONALD R
权利人:WALTER REED ARMY INST OF RES W; AI J LIN; JIAN GUAN; QUAN ZHANG; SKILLMAN DONALD R
摘要:The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and P.vivax strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs,. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.

专利号:US-2010137421-A1
优先权日:2006-11-08
标题 :Small molecule therapeutics, synthesis of analogues and derivatives and methods of use
发明人：THEODORAKIS EMMANUEL; BATOVA AYSE
权利人:THEODORAKIS EMMANUEL; BATOVA AYSE
摘要:Provided herein are compounds that are inducers of apoptosis activators of caspases and pharmaceutically acceptable derivatives thereof. Also provided are methods of synthesis of the compounds and methods for treatment of diseases in which there is uncontrolled cell growth and spread of abnormal cells, such as cancers, by administering the compounds.

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.