CAS: 103404-90-6; D-Alpha-Hydroxyglutaric Acid Disodium
该化合物是一种源自(R)-2-氢氧二丙烷酸的手性钠盐,通常用于有机合成和制药用途,其主要优点包括高对称纯度,对不对称合成和立体选择性反应具有价值;化合物在水和极地溶剂中表现出良好的溶解性,便于其在水反应系统中使用;在标准条件下保持稳定,确保了催化和口服测量工艺的可靠性能;此外,它作为生产精细化学和活性药物成分(API)的多用途中间体,在这种物质和活性药物成分中,精确的立体化学学至关重要;钠盐形式加强了工业规模应用的处理和兼容性.
- 英文名称D-Alpha-Hydroxyglutaric Acid Disodium
- 中文名称(R)-2-羟基戊二酸二钠盐
- IUPAC名称sodium (R)-2-hydroxypentanedioate
- 其它别名(R)-2-Hydroxypentanedioic Acid; Sodium (R)-2-Hydroxypentanedioate
- CAS编号103404-90-6
- MFCD编号:MFCD00069573
- 分子式:C5H6Na2O5分子量:192.08
- 产品CID: 68576
- 产品分类生物化工 → 氨基酸及其衍生物 → 谷氨酸类衍生物
- 相似结构搜索
- InChIKey: DZHFTEDSQFPDPP-HWYNEVGZSA-L
- DZHFTEDSQFPDPP-HWYNEVGZSA-L
- 计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数2.0
物理性质
上下游产品
L-glutamic acid (2S)-tetrahydro-5-oxofuran-2-carboxylic acid(R)-5-Oxo-tetrahydro-furan-2-carboxylic acid 4-bromo-phenyl ester (R)-2-(2-Nitro-benzoyloxy)-pentanedioic acid dimethyl ester (R)-2-(2,6-Dinitro-benzoyloxy)-pentanedioic acid dimethyl ester (R)-2-(3,5-Dinitro-benzoyloxy)-pentanedioic acid dimethyl ester合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399002-1,4-丁二醇
2905142000-仲丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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📌 第三方产品分析报告
主要参考文献
1. Kranendijk, M., Struys, E.A., Salomons, G.S., et al. Progress in understanding 2-hydroxyglutaric acidurias. J.Inherit.Metab.Dis. 35(4), 571-587 (2012). 2. Kranendijk, M., Struys, E.A., Van Schaftingen, E., et al. IDH2 Mutations in Patients with D-2-Hydroxyglutaric Aciduria. Science 330(6002), 336 (2014). 3. Struys, E.A., Salomons, G.S., Achouri, Y., et al. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria. American Journal of Human Genetics 76, 358-360 (2005). 4. Reeves, H.C., and Ajl, S.J. Alpha-hydroxyglutaric acid synthetase. J. Bacteriol. 84(1), 186-187 (1962).合成参考文献
参考文献:10.1038/s41591-018-0095-6
摘要:Bunse L, Pusch S, Bunse T, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Eisel J, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger MC, Harter PN, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende C, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suvà ML, Niemeyer BA, von Deimling A, Wick W, Platten M. Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. Nat Med. 2018 Aug;24(8):1192–203. doi: 10.1038/s41591-018-0095-6.
参考文献:10.1007/s11082-025-08260-7
摘要:Cherkasova OP, Kuznetsov SA, Rybak AA, Konnikova MR, Utkin DE, Nikolaev NA. Terahertz nanoantenna sensor for detection of biomarker L-2-Hydroxyglutarate, design optimization and testing. Opt Quant Electron. 2025 May 26;57(6). doi: 10.1007/s11082-025-08260-7.
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