苯乙醇置于1-Butyl-3-Methylimidazolium Tetrachloroindate体系中,化学反应 0.07H,反应生成乙酸苯乙酯 参考文献:[c4Mim][incl4]: An Efficient Catalyst-Medium For Alkoxymethylation Of Alcohols And Their Interconversion To Acetates And Tms-Ethers 标题:[c4Mim][incl4]: An Efficient Catalyst-Medium For Alkoxymethylation Of Alcohols And Their Interconversion To Acetates And Tms-Ethers 摘要:摘要 提出了一种简单,绿色且选择性强的方法,利用lewis酸性室温离子液体[c4Mim][incl4]作为催化剂和反应介质,在常温,微波和超声辐射下,对一级和二级醇进行甲氧基甲基化和乙氧基甲基化.在该催化系统中,相应的mom和eom醚以非常好的收率和短时间的反应获得.此外,该催化系统还用于在热条件及微波和超声辐射下,将这些保护醇温和高效地转化为相应的醋酸酯和三甲基硅醚. Doi:10.1016/j.Crci.2010.08.006
专利信息
专利号:US-3992413-A 优先权日:1975-07-25 标 题 :Intermediates in the synthesis of prostaglandins 发明人:TAUB DAVID; WENDLER NORMAN L 权利人:MERCK & CO INC 摘要:The invention relates to a new and novel synthesis of prostaglandin E 2 , and it particularly relates to a novel process starting with relatively inexpensive starting materials. The invention further relates to a synthesis which is readily adaptable for large scale processing because of the high yields in the individual reaction steps. n The invention further relates to novel compounds formed as intermediates in the synthesis of prostaglandin E 2 . The invention still further relates to synthetic analogs and known metabolites of prostaglandin E 2 and prostaglandin E 1 , useful as standards in certain biological assays for determining prostaglandin-like activity.
专利号:EP-0842924-B1 优先权日:1996-11-14 标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists 发明人:WRIGHT STEPHEN WAYNE 权利人:PFIZER 摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o
专利号:WO-9216541-A1 优先权日:1991-03-12 标 题 :Synthesis of sialic acid and synthetic intermediate therefor 发明人:SHIBA TETSUO; TESHIMA TADASHI; YAMAMOTO TOSHIHIRO 权利人:KANTO ISHI PHARMA CO LTD 摘要:An efficient synthesis of sialic acid (N-acetylneuramic acid) useful as the starting material of medicines, a synthetic intermediate therefor, isosialic acid as an isomer of sialic acid, synthesis thereof, and a synthetic intermediate therefor. Sialic acid is synthesized from D-glucose and oxaloacetic acid through the intermediates (Ia) and (IIIa), while isosialic acid represented by formula (IV) is synthesized from an isomer of the intermediate (Ia).
专利号:US-4182719-A 优先权日:1977-05-17 标题 :Synthesis of optically active vitamin E 发明人:COHEN NOAL; SAUCY GABRIEL 权利人:HOFFMANN LA ROCHE 摘要:Synthesis of optically active vitamin E from 2-methyl-5-oxotetrahydro-2-furoic acid including intermediates in this synthesis.
专利号:US-3732204-A 优先权日:1967-07-17 标题 :Synthesis of acronycine and related compounds 发明人:BECK J 权利人:LILLY CO ELI 摘要:THE TOTAL SYNTHESIS OF ACRONYCINIC AND RELATED COMPOUNDS FROM READILY AVAILABLE STARTING MATERIALS IS DESCRIBED, AS ARE VARIOUS CLASSES OF INTRMEDIATES USEFUL IN THE SYNTHESIS.
专利号:US-4208332-A 优先权日:1977-05-17 标 题:Synthesis of optically active vitamin E 发明人:COHEN NOAL; SAUCY GABRIEL 权利人:HOFFMANN LA ROCHE 摘要:Synthesis of optically active vitamin E from 2-methyl-5-oxotetrahydro-2-furoic acid including intermediates in this synthesis.
[参考文献]: Chia-Hung Kuo, Et Al. Enzymatic Synthesis Of Rose Aromatic Ester (2-Phenylethyl Acetate) By Lipase. J Sci Food Agric. 2012 Aug 15;92(10):2141-7. [参考文献]: D Mcginty, Et Al. Fragrance Material Review On Phenethyl Acetate. Food Chem Toxicol. 2012 Sep:50 Suppl 2:S491-7. [参考文献]: Dai Chen, Et Al. Impact Of Addition Of Aromatic Amino Acids On Non-Volatile And Volatile Compounds In Lychee Wine Fermented With Saccharomyces Cerevisiae Merit.Ferm. Int J Food Microbiol. 2014 Jan 17:170:12-20. [参考文献]: G I Rumiantsev, Et Al. [参考文献]: Gig Sanit. 1987 Oct:(10):83-4. [参考文献]: Inna Guterman, Et Al. Generation Of Phenylpropanoid Pathway-Derived Volatiles In Transgenic Plants: Rose Alcohol Acetyltransferase Produces Phenylethyl Acetate And Benzyl Acetate In Petunia Flowers. Plant Mol Biol. 2006 Mar;60(4):555-63.
合成参考文献
参考文献:10.1007/s10482-011-9622-x 摘要:Valle-Rodríguez JO, Hernández-Cortés G, Córdova J, Estarrón-Espinosa M, Díaz-Montaño DM. Fermentation of Agave tequilana juice by Kloeckera africana: influence of amino-acid supplementations. Antonie Van Leeuwenhoek. 2012 Feb;101(2):195–204. doi: 10.1007/s10482-011-9622-x.