CAS: 86801-04-9; 1-(3-Acetylphenyl)Thiourea

上下游产品

CAS号99-03-6 3'-氨基苯乙酮

📜间氨基苯乙酮,苯甲酰基异硫氰酸酯置于sodium Hydroxide体系中,用 二氯甲烷,四氢呋喃,水 作为反应溶剂,化学反应 15.0H,以72%的收率获得产物1-(3-乙酰苯基)-2-硫脲
参考文献:Discovery Of Multitarget Agents Active As Broad-Spectrum Antivirals And Correctors Of Cystic Fibrosis Transmembrane Conductance Regulator For Associated Pulmonary Diseases
标题:Discovery Of Multitarget Agents Active As Broad-Spectrum Antivirals And Correctors Of Cystic Fibrosis Transmembrane Conductance Regulator For Associated Pulmonary Diseases
摘要:Enteroviruses (Evs) Are Among The Most Frequent Infectious Agents In Humans Worldwide And Represent The Leading Cause Of Upper Respiratory Tract Infections. No Drugs For The Treatment Of Ev Infections Are Currently Available. Recent Studies Have Also Linked Ev Infection With Pulmonary Exacerbations,Especially In Cystic Fibrosis (Cf) Patients,And The Importance Of This Link Is Probably Underestimated. The Aim Of This Work Was To Develop A New Class Of Multitarget Agents Active Both As Broad-Spectrum Antivirals And As Correctors Of The F508Del-Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) Folding Defect Responsible For >90% Of Cf Cases. We Report Herein The Discovery Of The First Small Molecules Able To Simultaneously Act As Correctors Of The F508Del-Cftr Folding Defect And As Broad-Spectrum Antivirals Against A Panel Of Evs Representative Of All Major Species.
DOI:10.1021/acs.Jmedchem.6B01521