CAS: 86639-51-2; 7-Ethylcamptothecin 1-Oxide

英文名称7-Ethylcamptothecin 1-Oxide
中文名称7-乙基喜树碱氮氧化物
CAS编号86639-51-2
分子式:C22H20N2O5分子量:392.411
产品CID: 2387678
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: MKHVWVFNQAFAKW-QFIPXVFZSA-N
1S/C22H20N2O5/c1-3-12-13-7-5-6-8-17(13)24(28)19-14(12)10-23-18(19)9-16-15(20(23)25)11-29-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数2.0

MSDS等安全信息

警示词warning
危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

上下游产品

CAS号86639-52-3 7-乙基-10羟基喜树碱 | CAS号107072-47-9 7-ethyl-12-hydr... | CAS号97682-44-5 伊立替康

合成工艺路线路线简述

78287-27-1 = 86639-51-2
反应条件:1.1 Reagents: Acetic Acid,Acetic Anhydride,Hydrogen Peroxide Solvents: Water; Rt -> 55 °C; 5 H,55 °C; 5 H,55 °C
标题:Synthesis Of 7-Ethyl-10-Hydroxycamptothecin
作者:An,Hui; Et Al
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2005 卷标:36(5) 页码:264-265]

7689-03-4 = 86639-51-2
反应条件:1.1 Reagents: Ferrous Sulfate Heptahydrate Solvents: Water1.2 Reagents: Acetic Acid,Sulfuric Acid1.3 Reagents: Hydrogen Peroxide2.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Acetic Anhydride
标题:Synthesis Of 7-Ethyl-10-Hydroxycamptothecin And Proposed Reaction Mechanism
作者:Lei,Ying-Jie; Et Al
参考文献:Chemical Research In Chinese Universities 日期:2001 卷标:17(1) 页码:69-72]

7689-03-4 + 542-78-9 = 86639-51-2
反应条件:1.1 Reagents: Sulfuric Acid,Hydrogen Peroxide Catalysts: Ferrous Sulfate Heptahydrate Solvents: Acetic Acid,Water; 0 - 5 °C; 1 H,0 - 5 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 82.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water; 5 H,75 °C
标题:Synthesis Of Related Substances Of Irinotecan
作者:Zhang,Shu-Qi; Et Al
参考文献:Shenyang Yaoke Daxue Xuebao 日期:2016 卷标:33(6) 页码:434-437]

78287-27-1 = 86639-51-2
反应条件:1.1 Reagents: Hydrogen Peroxide
标题:Synthesis And Antitumor Activity Of 20(S)-Camptothecin Derivatives: Carbamate-Linked,Water-Soluble Derivatives Of 7-Ethyl-10-Hydroxycamptothecin
作者:Sawada,Seigo; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1991 卷标:39(6) 页码:1446-54]

7689-03-4 = 86639-51-2
反应条件:1.1 Reagents: Sulfuric Acid,Ferrous Sulfate,Hydrogen Peroxide Solvents: Acetic Acid,Water2.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid
标题:Improved Method For The Synthesis Of Irinotecan
作者:Li,Yuyan; Et Al
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2001 卷标:11(4) 页码:238-240]

7689-03-4 = 86639-51-2
反应条件:1.1 Reagents: Acetic Acid,Sulfuric Acid,Ferrous Sulfate Solvents: Water; Rt1.2 Reagents: Ferrous Sulfate,Hydrogen Peroxide Solvents: Water; Rt; 10 Min,Rt2.1 Reagents: Acetic Acid,Acetic Anhydride,Hydrogen Peroxide Solvents: Water; Rt -> 55 °C; 5 H,55 °C; 5 H,55 °C
标题:Synthesis Of 7-Ethyl-10-Hydroxycamptothecin
作者:An,Hui; Et Al
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2005 卷标:36(5) 页码:264-265

📜喜树碱置于硫酸,双氧水,Iron(II) Sulfate体系中,用水,溶剂黄146 作为反应溶剂,化学反应 13.5H,反应生成 7-乙基喜树碱1-氧化物
参考文献:Synthesis And Antitumor Activity Of 20(S)-Camptothecin Derivatives: Carbamate-Linked,Water-Soluble Derivatives Of 7-Ethyl-10-Hydroxycamptothecin.
标题:Synthesis And Antitumor Activity Of 20(S)-Camptothecin Derivatives: Carbamate-Linked,Water-Soluble Derivatives Of 7-Ethyl-10-Hydroxycamptothecin.
摘要:Nevel 36衍生物(6个)通过单氨基甲酸酯连接,将7-乙基-10-羟基喜树碱(4)的酚羟基与二胺结合,经过合成并在体内评估了它们的抗肿瘤活性.这些衍生物作为盐酸盐在水中有较好的溶解度,且其e内酯环保持完整,并表现出显著的抗肿瘤活性.其中一种衍生物6-27对l1210白血病和其他小鼠肿瘤显示出极佳的活性.其三水合盐酸盐(cpt-11)的结构通过光谱学和结晶学方法得以确定.
DOI:10.1248/cpb.39.1446