CAS: 817638-68-9; 3-Azido-7-Hydroxychromen-2-One

该化合物是属于氟氯素类的化学化合物,特别是科马林的衍生物;该化合物具有3位置的Azido组(-N3)和7位置的氢氧基(-OH)组(-OH),它有助于其独特的化学特性; 组的存在可以带来有趣的再活动,使它有可能成为有机合成和药化学中各种应用的候选物; 氢氧基组在极溶剂中强化其溶性,并可能影响其生物活动; 该化合物可能展示荧光体,并有可能用于光化学研究; 此外,其结构特征表明,它可以与生物系统互动,从而引起对药理学研究的兴趣; 然而,具体的生物活动和安全特征需要通过经验研究作进一步调查;

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CAS号79418-42-1 N-(7-hydroxy-2-... | CAS号69019-75-6 3-acetamido-2-o... | CAS号95-01-2 2,4-二羟基苯甲醛 | CAS号543-24-8 N-乙酰甘氨酸 | CAS号79418-41-0 3-氨基-7-羟基香豆素

合成工艺路线路线简述

  • 79418-42-1 = 817638-68-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 1 H,Reflux1.2 Reagents: Sodium Nitrite; 15 Min,0 °C1.3 Reagents: Sodium Azide; 30 Min,0 °C
    标题:Generation Of Profluorescent Isoindoline Nitroxides Using Click Chemistry
    作者:Morris,Jason C.; Mcmurtrie,John C.; Bottle,Steven E.; Fairfull-Smith,Kathryn E.
    参考文献:Journal Of Organic Chemistry 日期:2011 卷标:76(12) 页码:4964-4972]

    79418-42-1 = 817638-68-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Reflux; 0 - 5 °C1.2 Reagents: Sodium Nitrite,Sodium Azide; 40 Min,0 - 5 °C; 8 H,Rt
    标题:Design And Synthesis Of 3-Triazolo-Coumarins And Their Applications In Scavenging Radicals And Protecting Dna
    作者:Liu,Zhihui; Wang,Yingnan; Sun,Jingbo; Yang,Yang; Liu,Qingwen; Et Al
    参考文献:Chemical Research In Chinese Universities 日期:2015 卷标:31(4) 页码:526-533]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Sodium Acetate Solvents: Acetic Anhydride; 4 H,Reflux1.2 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Ethanol,Water; 5 Min,Cooled1.3 Reagents: Sodium Azide; 15 Min,Cooled
    标题:A Dnazyme-Augmented Bioorthogonal Catalysis System For Synergistic Cancer Therapy
    作者:You,Yawen; Liu,Hao; Zhu,Jiawei; Wang,Yibo; Pu,Fang; Et Al
    参考文献:Chemical Science 日期:2022 卷标:13(26) 页码:7829-7836]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Acetic Anhydride,Sodium Acetate; 4 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 1 H,Reflux1.3 Reagents: Water; Cooled1.4 Reagents: Sodium Nitrite; 5 - 10 Min,Cooled1.5 Reagents: Sodium Azide; 15 Min,Cooled
    标题:Near-Infrared Light Dual-Promoted Heterogeneous Copper Nanocatalyst For Highly Efficient Bioorthogonal Chemistry In Vivo
    作者:You,Yawen; Cao,Fangfang; Zhao,Yajie; Deng,Qingqing; Sang,Yanjuan; Et Al
    参考文献:Acs Nano 日期:2020 卷标:14(4) 页码:4178-4187]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Sodium Acetate Solvents: Acetic Anhydride; 4 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Ethanol; 1 H,Reflux1.3 Reagents: Sodium Nitrite; 5 - 10 Min,0 °C1.4 Reagents: Sodium Azide; 15 Min
    标题:A Fluorogenic 1,3-Dipolar Cycloaddition Reaction Of 3-Azidocoumarins And Acetylenes
    作者:Sivakumar,Krishnamoorthy; Xie,Fang; Cash,Brandon M.; Long,Su; Barnhill,Hannah N.; Et Al
    参考文献:Organic Letters 日期:2004 卷标:6(24) 页码:4603-4606]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Sodium Acetate Solvents: Acetic Anhydride; 4 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Ethanol; 1 H,Reflux; Cooled1.3 Reagents: Sodium Nitrite; 5 - 10 Min,Cooled1.4 Reagents: Sodium Azide; Cooled; 15 Min,Cooled
    标题:Clickable Degradable Aliphatic Polyesters Via Copolymerization With Alkyne Epoxy Esters: Synthesis And Postfunctionalization With Organic Dyes
    作者:Teske,Nele S.; Voigt,Julia; Shastri,V. Prasad
    参考文献:Journal Of The American Chemical Society 日期:2014 卷标:136(29) 页码:10527-10533]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Acetic Anhydride,Sodium Acetate; 4 H,110 - 120 °C; 120 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 1 H,Reflux1.3 Reagents: Sodium Nitrite Solvents: Water; 5 - 10 Min,Cooled1.4 Reagents: Sodium Azide; Cooled; 15 Min,Cooled
    标题:Face-Selective Fluorogenic Cycloaddition Reaction Between Coumarin Azides And Sugar Terminal Alkynes: An Experimental And Computational Study
    作者:Rajaganesh,Ramanathan; Ravinder,Pawar; Subramanian,Venkatesan; Mohan Das,Thangamuthu
    参考文献:Carbohydrate Research 日期:2011 卷标:346(15) 页码:2327-2336]

    69019-75-6 = 817638-68-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 1 H,Reflux1.2 Reagents: Sodium Nitrite Solvents: Water; 15 Min,Cooled1.3 Reagents: Sodium Azide; Cooled; 20 Min,Cooled
    标题:Catalyst-Free Conjugation And In Situ Quantification Of Nanoparticle Ligand Surface Density Using Fluorogenic Cu-Free Click Chemistry
    作者:Jolck,Rasmus I.; Sun,Honghao; Berg,Rolf H.; Andresen,Thomas L.
    参考文献:Chemistry - A European Journal 日期:2011 卷标:17(12) 页码:3326-3331]

    69019-75-6 = 817638-68-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 1 H,Reflux1.2 Reagents: Sodium Nitrite Solvents: Water; 15 Min,Cooled1.3 Reagents: Sodium Azide; Cooled; 15 Min,Cooled
    标题:High Spatiotemporal Control Of Spontaneous Reactions Using Ultrasound-Triggered Composite Droplets
    作者:Bezagu,Marine; Errico,Claudia; Chaulot-Talmon,Victor; Monti,Fabrice; Tanter,Mickael; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2014 卷标:136(20) 页码:7205-7208]

    20769-30-6 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Sodium Acetate Solvents: Acetic Anhydride; 4 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Ethanol; 1 H,Rt1.3 Reagents: Sodium Nitrite Solvents: Water; 5 - 10 Min,0 °C1.4 Reagents: Sodium Azide; 0 °C; 15 Min,0 °C
    标题:A Biocompatible Heterogeneous Mof-Cu Catalyst For In Vivo Drug Synthesis In Targeted Subcellular Organelles
    作者:Wang,Faming; Zhang,Yan; Liu,Zhengwei; Du,Zhi; Zhang,Lu; Et Al
    参考文献:Angewandte Chemie 日期:2019 卷标:58(21) 页码:6987-6992]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Sodium Acetate Solvents: Acetic Anhydride; 4 H,Reflux1.2 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Ethanol,Water; 10 Min,Cooled1.3 Reagents: Sodium Azide; Cooled; 15 Min,Cooled
    标题:Synthesis Of Novel Estrogen Receptor Antagonists Using Metal-Catalyzed Coupling Reactions And Characterization Of Their Biological Activity
    作者:Jiang,Xiang-Rong; Wang,Pan; Smith,Carolyn L.; Zhu,Bao Ting
    参考文献:Journal Of Medicinal Chemistry 日期:2013 卷标:56(7) 页码:2779-2790]

    69019-75-6 = 817638-68-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 1 H,Reflux1.2 Reagents: Sodium Nitrite; 10 - 15 Min,Cooled1.3 Reagents: Sodium Azide; Cooled; 1 H,Cooled
    标题:Coumarin-Based Fluorescent Probes For H2S Detection
    作者:Li,Wenhua; Sun,Wei; Yu,Xiaoqiang; Du,Lupei; Li,Minyong
    参考文献:Journal Of Fluorescence 日期:2013 卷标:23(1) 页码:181-186]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Solvents: Acetic Anhydride; 6 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Ethanol-D,Water; 1 H,Reflux1.3 Reagents: Sodium Nitrite Solvents: Water; 15 Min,Cooled1.4 Reagents: Sodium Azide; Cooled; 30 Min,Cooled
    标题:Self-Triggered Click Reaction In An Alzheimer'S Disease Model: In Situ Bifunctional Drug Synthesis Catalyzed By Neurotoxic Copper Accumulated In Amyloid-Beta Plaques
    作者:Du,Zhi; Yu,Dongqin; Du,Xiubo; Scott,Peter; Ren,Jinsong; Et Al
    参考文献:Chemical Science 日期:2019 卷标:10(44) 页码:10343-10350]

    95-01-2 + 543-24-8 = 817638-68-9
    反应条件:1.1 Reagents: Sodium Acetate Solvents: Acetic Anhydride; 4 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Ethanol; 1 H,Reflux1.3 Reagents: Sodium Nitrite Solvents: Water; 10 Min,Cooled1.4 Reagents: Sodium Azide; Cooled; 15 Min,Cooled
    标题:Multifunctional Polypeptide-Peo Nanoreactors Via The Hydrophobic Switch
    作者:Wu,Yuzhou; Wang,Tao; Ng,David Y. W.; Weil,Tanja
    参考文献:Macromolecular Rapid Communications 日期:2012 卷标:33(17) 页码:1474-1481]

    79418-41-0 = 817638-68-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 15 Min,0 - 5 °C1.2 Reagents: Sodium Azide; 1 H,0 - 5 °C
    标题:Highly Efficient Catalytic Performance On Cuaac Reaction By Polymer-Like Supramolecular Self-Assemblies-Cu(I) In Aqueous Solution
    作者:Deng,Bin; Yang,Jing; Guo,Mengbi; Yang,Rui
    参考文献:Applied Organometallic Chemistry 日期:2022 卷标:36(6)
📜3-Acetamido-2-Oxo-2H-Chromen-7-Yl Acetate置于盐酸,Sodium Nitrite,Sodium Azide体系中,用 乙醇,水 作为反应溶剂,化学反应 1.5H,以32%的收率获得产物3-叠氮基-7-羟基氧杂萘邻酮
参考文献:锌 (II) 离子荧光指示剂中的集成和被动 1,2,3-三唑基:热力学和动力学评估
标题:锌 (II) 离子荧光指示剂中的集成和被动 1,2,3-三唑基:热力学和动力学评估
摘要:除了作为分子共轭化学中的共价接头外,由铜 (I) 催化的叠氮化物-炔环加成反应产生的 1,2,3-三唑基部分作为金属离子配体的功能受到了相当多的关注.在这项工作中,我们表征了在荧光锌 (II) 指示剂开发的背景下,在多齿配体支架中加入 1,2,3-三唑基对金属配位的热力学和动力学影响.配体l14,Brl14和fl14(1,4-异构体)包含 1,4-二取代的 1,2,3-三唑基,该基团能够与多齿内的二(2-甲基吡啶氨基)(Dpa) 部分结合的锌 (II) 结合配体支架.因此,1,4-异构体中的1,2,3-三唑基在螯合中是"整合"的.1,5-异构体l15,Brl15和fl15含有 1,2,3-三唑基,它们被排除在锌 (II) 配位之外.这些 1,2,3-三唑基是"被动接头".使用1 H NMR 光谱和等温滴定量热法 (Itc)鉴定溶液中化学计量比为 2:1(配体/金属)的锌 (II) 配合
DOI:10.1021/ic302798U

海关参考信息

专利信息


专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-8912323-B2
优先权日:2009-10-30
标题 :Multifunctional small molecules
发明人：BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P
权利人:BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P; UNIV MICHIGAN
摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.

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合成参考文献


摘要:Agrahari, A. K.; Mishra, A.; Tiwari, V. K., Science of Synthesis, (2021) , 136.
摘要:Svatunek, D.; Houk, K. N., Science of Synthesis, (2021) , 409.
参考文献:10.1016/j.foodchem.2014.04.061
摘要:Lu L, Yang L, Cai H, Zhang L, Lin Z, Guo L, Qiu B, Chen G. Determination of flumioxazin residue in food samples through a sensitive fluorescent sensor based on click chemistry. Food Chem. 2014 Nov 01;162():242–6. doi: 10.1016/j.foodchem.2014.04.061.
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