专利号:EP-2666771-A1 优先权日:2012-05-24 标题 :Synthesis of Aminocyclopentanetriol Derivatives 发明人:STERK DAMJAN; CASAR ZDENKO 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor. nThe present invention provides in particular a process for the preparation of a compound of formula Vn ncomprising: na) providing a compound of formula IVn n, and nb) reducing the compound of formula IV with activated zinc in the presence of copper to give the compound of formula V.
专利号:US-9278972-B2 优先权日:2011-12-23 标题 :Synthesis of triazolopyrimidine compounds 发明人:MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.
专利号:US-6765091-B1 优先权日:1999-08-30 标题:Oligosaccharides derived from ribose-ribitol-phosphate, and vaccines containing them 发明人:BENCOMO VICENTE GUILLERMO VERE; ROY RENE 权利人:UNIV LA HABANA; UNIV OTTAWA 摘要:The present invention relates to the field of the Medicine, in particular with the chemical synthesis of oligosaccharide mixtures derived of ribose-ribitol-phosphate, which are used as active principle in vaccines for the prevention of infections caused by Haemophilus influenzae type b (Hib), as well as with the vaccines containing said oligosaccharide mixtures. n The oligasaccharide mixtures obtained by chemical synthesis of the present invention, comprise repeating units of formulae (phosphate-ribosa-ribitol)n or (ribose-ribitol-phosphate)n of at least 5 compounds of structure A or B, which represent the repeating unit of the capsular polysaccharide of Haemophilus influenzae type b and differ only by n, being n a value contained between 4 and 25 (n≧4 y≦25), and wherein R 1 or R 2 is a spacer for conjugation to a carrier, with the condition of R 1 =spacer if R 2 =H, or R 2 =spacer if R 1 =H. n The invention also is related with the immunogens containing such oligosaccharide mixtures, with the vaccines containing said immunogens and with the methods to prepare these oligosaccharides as mixtures. Furthermore, the invention includes the use of the vaccines, alone or combined with other vaccines, for the prevention of the infections caused by Haemophilus influenzae type b.
专利号:US-2014371449-A1 优先权日:2011-12-23 标题 :Synthesis of Triazolopyrimidine Compounds
专利号:EP-2794575-A1 优先权日:2011-12-23 标题 :Synthesis of triazolopyrimidine compounds
专利号:EP-2794575-B1 优先权日:2011-12-23 标题 :Synthesis of triazolopyrimidine compounds
参考文献:10.1055/s-0039-1691699 摘要:Liu J, Dong Z, Chang C, Geng J, Liu Y, Du Y. Stereoselective Total Synthesis of Arundinolides A and B. Synthesis. 2020 Feb 05;52(10):1576–84. doi: 10.1055/s-0039-1691699.