CAS: 5351-17-7; 4-Aminobenzohydrazide

该化合物是一种有机化合物,其特征为氨基氨基酸组和附于苯并酸结构的氢氮功能组.该化合物一般是白色至白色晶状固体,可溶于水和酒精等极地溶剂.该化合物的特性使其在各种应用中有用,包括作为有机合成的试剂和由于其生物活动而有可能用于制药.氨基氨基酸组的存在允许进一步衍生,使其在化学反应中成为多功能中间体.此外,4-氨基苯甲酸氢氮酸二甲酸可能会表现出抗微生物和抗炎特性,这对药用化学具有兴趣.与许多氢氮化合物一样,它也可能参与凝聚反应,导致形成更为复杂的分子.适当的处理和储存与许多有机化合物一样,对于确保安全和稳定至关重要.

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CAS号619-45-4 4-氨基苯甲酸甲酯 | CAS号94-09-7 对氨基苯甲酸乙酯 | CAS号150-13-0 对氨基苯甲酸 | CAS号99-77-4 对硝基苯甲酸乙酯 | CAS号636-97-5 4-硝基苯肼 | CAS号4005-02-1 4-(2-甲基-4-氧代喹唑啉... | CAS号10073-94-6 4-(2-methyl-4-o... | CAS号619-50-1 4-硝基苯甲酸甲酯 | CAS号16106-38-0 4-氨基苯甲酰氯 | CAS号62-23-7 对硝基苯甲酸 | CAS号14070-13-4 4-[3-(4-aminoph... | CAS号35219-13-7 4-(1,3,4-噁二唑-2-基)苯胺 | CAS号32058-82-5 5-(4-氨基苯基)-1,3,... | CAS号2425-95-8 2,5-二(4-氨基苯基)-1... | CAS号556-18-3 4-氨基苯甲醛 | CAS号127786-22-5 N-[4-(hydrazine... | CAS号127786-20-3 N-(benzylidenea... | CAS号127786-18-9 N-[(E)-benzylid... | CAS号127786-25-8 N-[4-(hydrazine... | CAS号127786-24-7 N-[4-(hydrazine...

合成工艺路线路线简述

    📜苯佐卡因置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 5.0H,以90%的收率获得产物4-氨基苯甲酰肼
    参考文献:N '-[4-[(取代的亚氨基)甲基]亚苯亚甲基]-取代的苯甲酰肼:合成,抗菌,抗病毒和抗癌评估以及 Qsar 研究
    标题:N '-[4-[(取代的亚氨基)甲基]亚苯亚甲基]-取代的苯甲酰肼:合成,抗菌,抗病毒和抗癌评估以及 Qsar 研究
    摘要:抽象的 多种n '-[4-[(取代亚氨基)甲基]亚苄基]-取代苯甲酰肼已被合成并评估其抗菌和抗癌潜力.抗菌活性测试结果表明最有效的抗菌药物具有 P Mic 上午= 1.51.合成的化合物具有抑菌和抑真菌作用.抗病毒活性评估结果表明,合成的酰肼衍生物在亚毒浓度下均不能抑制病毒复制.针对 Hiv-2 Rod 株的抗 Hiv 筛选结果表明,一种化合物更有效(Ic 50>=1μg /cm 3)比标准药物奈韦拉平(Ic 50 >= 4 μg/cm 3),另一个是等势的(Ic 50>=4微克/厘米3).针对 Hct116 和 Mcf7 癌细胞系最有效的抗癌药物具有ic 值 50分别=19和18μg/cm 3 . Qsar 分析表明维纳指数 (W) 和最低未占分子轨道能量 (Lumo) 在描述合成化合物的抗菌活性方面的重要性. 图解摘要
    DOI:10.1007/s00706-012-0877-3

    海关参考信息

    专利信息


    专利号:US-8652442-B2
    优先权日:2008-11-03
    标题 :Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
    发明人：PIWNICA-WORMS DAVID; GROSS SHIMON; SHARMA VIJAY; GAMMON SETH
    权利人:PIWNICA-WORMS DAVID; GROSS SHIMON; SHARMA VIJAY; GAMMON SETH; UNIV WASHINGTON
    摘要:Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.

    专利号:US-8895747-B2
    优先权日:2009-07-27
    标 题 :Method and substances for preparation of N-substituted pyridinium compounds
    发明人：HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
    权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
    摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

    专利号:WO-2014051445-A1
    优先权日:2012-09-26
    标 题:Pyrrole-3,4-dicarboxamides
    发明人：PACIOREK PATRYCJA; SZKLARZEWICZ JANUSZ
    权利人:UNIV JAGIELLOŃSKI
    摘要:The invention relates to the pyrrole derivatives with the general formula in which R 1 is alkyl group C 1 - C 10 , straight or branched, R 2 is -H, -C1, -OH, -NH 2 or -OCH 3 . The invention includes also the method of the synthesis of pyrrole derivatives in the reaction of ketoanilide with hydrazide, with the use of vanadium compound as a reaction promoter.

    专利号:MX-2013007745-A
    优先权日:2013-07-02
    标题 :Synthesis of a derivative of 5-aminosalicilic acid with antioxidant activity.

    专利号:CN-109293669-B
    优先权日:2018-10-16
    标 题:A kind of fluorescent probe for detecting hypochlorous acid and its synthesis method and application

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    主要参考文献


    1: Arvadia P, Narwaley M, Whittal RM, Siraki AG. 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites. Arch Biochem Biophys. 2011 Nov;515(1-2):120-6. doi: 10.1016/j.abb.2011.07.015. Epub 2011 Aug 9. doi: 10.1107/S2056989015020319. eCollection 2015 Dec 1.
    3: Huang J, Smith F, Panizzi P. Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic acid hydrazide analogs. Arch Biochem Biophys. 2014 Apr 15;548:74-85. doi: 10.1016/j.abb.2014.02.014. Epub 2014 Mar 13.
    4: Tiyerili V, Camara B, Becher MU, Schrickel JW, Lütjohann D, Mollenhauer M, Baldus S, Nickenig G, Andrié RP. Neutrophil-derived myeloperoxidase promotes atherogenesis and neointima formation in mice. Int J Cardiol. 2016 Feb 1;204:29-36. doi: 10.1016/j.ijcard.2015.11.128. Epub 2015 Nov 22. doi: 10.1016/j.biocel.2015.09.006. Epub 2015 Sep 18. Epub 2006 Jan 19.

    合成参考文献


    参考文献:10.1007/s12010-014-0968-1
    摘要:Somtürk B, Kalın R, Özdemir N. Purification of Peroxidase from Red Cabbage (Brassica oleracea var. capitata f. rubra) by Affinity Chromatography. Applied Biochemistry and Biotechnology. 2014 May 31;173(7):1815–28. doi: 10.1007/s12010-014-0968-1.
    参考文献:10.1007/s00044-016-1756-y
    摘要:Popiołek Ł. Hydrazide–hydrazones as potential antimicrobial agents: overview of the literature since 2010. Medicinal Chemistry Research. 2016 Nov 25;26(2):287–301. doi: 10.1007/s00044-016-1756-y.
    参考文献:10.1042/bj3210503
    摘要:Kettle AJ, Gedye CA, Winterbourn CC. Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochem J. 1997 Jan 15;321 ( Pt 2)():503–8.
    参考文献:10.1007/bf02976622
    摘要:Nofal ZM, Fahmy HH, Mohamed HS. Synthesis and antimicrobial activity of new substituted anilinobenzimidazoles. Arch Pharm Res. 2002 Jun;25(3):250–7. doi: 10.1007/bf02976622.
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