CAS: 51798-45-9; (((S)-2-(((S)-5-Amino-1,5-Dioxo-1-(((S)-1-Oxopropan-2-yl)Amino)Pentan-2-yl)Amino)-1-((S)-2-Amino-3,4,5,6-Tetrahydropyrimidin-4-yl)-2-Oxoethyl)Carbamoyl)-L-Leucine
该化合物是静脉除尘器的强大和选择性抑制剂,一种蛋白解酶,可降解弹性体和其他细胞外基质蛋白.这种循环,来自微生物来源,具有很强的营养和肺炎异质特性,使它成为研究以静脉反应为媒介的生理和病理过程的宝贵工具.它的机制涉及通过模仿基质的转型状态,有效阻止低微摩尔浓度的静脉活性. 静脉呼吸道在水溶液中的稳定性和对非特定蛋白解的抗性增强了其在生物化学实验和研究应用中的效用.它对于组织改造,炎症和诸如肺炎和慢性阻塞性肺病(COPD)等疾病的调查特别有用,因为肺炎活动在其中起着关键作用.
- 英文名称(((S)-2-(((S)-5-Amino-1,5-Dioxo-1-(((S)-1-Oxopropan-2-yl)Amino)Pentan-2-yl)Amino)-1-((S)-2-Amino-3,4,5,6-Tetrahydropyrimidin-4-yl)-2-Oxoethyl)Carbamoyl)-L-Leucine
- 中文名称(2S)-2-[(4S)-2-氨基-1,4,5,6-四羟基4-嘧啶基]-N-[[[(1S)-1-羰基-3-甲基丁基]氨基]羰基]甘氨酰-N1-[(1S)-1-甲基-2-氧乙基-L-谷氨酸甲酰胺
- IUPAC名称(((S)-2-(((S)-5-amino-1,5-dioxo-1-(((S)-1-oxopropan-2-yl)amino)pentan-2-yl)amino)-1-((S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-oxoethyl)carbamoyl)-L-leucine
- 其它别名(2S)-2-[[(1S)-2-[[(2S)-5-Amino-1,5-Dioxo-1-[[(2S)-1-Oxopropan-2-Yl]Amino]Pentan-2-Yl]Amino]-1-[(6S)-2-Amino-1,4,5,6-Tetrahydropyrimidin-6-Yl]-2-Oxoethyl]Carbamoylamino]-4-Methylpentanoicacid; (2S)-2-[(4S)-2-Amino-3,4,5,6-Tetrahydro-4-Pyrimidinyl]-N-[[[(1
- CAS编号51798-45-9
- MFCD编号:MFCD00151180
- EINECS号:257-426-7
- FDA UNII编号:LX4Y75DOA7
- 分子式:C21H36N8O7分子量:512.57
- 产品CID: 1508160
- 产品分类生物化工 → 氨基酸及其衍生物 → 谷氨酸类衍生物
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
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2912110000-甲醛
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专利信息
专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.
专利号:US-5283293-A
优先权日:1990-12-14
标 题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.
专利号:US-5367072-A
优先权日:1990-12-14
标 题 :Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.
专利号:CA-2192697-A1
优先权日:1994-06-17
标 题 :Methods of synthesis of peptidyl argininals
专利号:AU-701503-B2
优先权日:1994-06-17
标题 :Methods of synthesis of peptidyl argininals
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Maxson T, Tietz JI, Hudson GA, Guo XR, Tai HC, Mitchell DA. Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins. J Am Chem Soc. 2016 Nov 23;138(46):15157-15166. Epub 2016 Nov 14.
2: Barros SC, Martins JA, Marcos JC, Cavaco-Paulo A. Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications. Enzyme Microb Technol. 2012 Feb 10;50(2):107-14. doi: 10.1016/j.enzmictec.2011.10.006. Epub 2011 Nov 7. doi: 10.1007/s11033-009-9916-5. Epub 2009 Nov 12. doi: 10.1016/j.actatropica.2009.07.015. Epub 2009 Jul 24. Epub 2006 Sep 8. Epub 2006 Mar 14.
11: Ahn MY, Hahn BS, Ryu KS, Hwang JS, Kim YS. Purification and characterization of a serine protease (CPM-2) with fibrinolytic activity from the dung beetles. Arch Pharm Res. 2005 Jul;28(7):816-22.
合成参考文献
参考文献:10.1016/0014-5793(93)80557-b
摘要:Sarubbi E, Seneci PF, Angelastro MR, Peet NP, Denaro M, Islam K. Peptide aldehydes as inhibitors of HIV protease. FEBS Lett. 1993 Mar 22;319(3):253–6. doi: 10.1016/0014-5793(93)80557-b.
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