N-重氮基氨基甲酸叔-丁基酯置于diiron Nonacarbonyl体系中,用 苯 作为反应溶剂,化学反应生成 双(叔丁氧羰基)胺 参考文献:Decomposition Of Sulfonyl Azides And Tert-Butyl Azidoformate By Transition Metal Carbonyls 标题:Decomposition Of Sulfonyl Azides And Tert-Butyl Azidoformate By Transition Metal Carbonyls 摘要: DOI:10.1021/jo00931A010
专利号:US-2022098170-A1 优先权日:2019-01-16 标 题 :Process for the synthesis of gepirone 发明人:COLOMBANO GIAMPIERO; BARBERO MAURO; GIOVENZANA GIOVANNI BATTISTA; ROLETTO JACOPO; PAISSONI PAOLO 权利人:PROCOS SPA 摘要:Disclosed is a process for the synthesis of gepirone of formula (I) from 8-(pyrimidin-2-yl)-5,8-diazaspiro[4,5]decan-5-ium bromide. The process according to the invention is economically efficient and easily industrially scalable.
专利号:US-12180182-B2 优先权日:2021-12-01 标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same 发明人:DAI MINGJI 权利人:PURDUE RESEARCH FOUNDATION 摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.
专利号:US-6756199-B1 优先权日:1994-02-23 标题:Peptide nucleic acid combinatorial libraries and improved methods of synthesis 发明人:COOK PHILLIP DAN; KIELY JOHN; SPRANKLE KELLY 权利人:ISIS PHARMACEUTICALS INC 摘要:New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are method of making random libraries of peptide nucleic acids using the fully preformed monomers. Chimeric oligomers and libraries of the same are also disclosed.
专利号:US-2024308959-A1 优先权日:2021-06-29 标 题:Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3 -methoxy-5-(m ethylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives 发明人:WU KAI; OOST RIK; SCHWEITZER-CHAPUT BERTRAND; ERIKSSON CARL ARNE MAGNUS; COESEMANS ERWIN 权利人:JANSSEN PHARMACEUTICALS INC 摘要:The present invention relates to novel chiral synthesis of mono- or di-substituted indole compounds of formula (I) n n n n n n n n n n n n wherein: n R 1 is H, R 2 is F and R 3 is H or CH 3 , n R 1 is H, CH 3 or F, R 2 is OCH 3 and R 3 is H and n R 1 is H, R 2 is OCH 3 and R 3 is CH 3 , n R 1 is CH 3 , R 2 is F and R 3 is H, n R 1 is CF 3 or OCF 3 , R 2 is H and R 3 is H, n R 1 is OCF 3 , R 2 is OCH 3 and R 3 is H and n R 1 is OCF 3 , R 2 is H and R 3 is CH 3 .
专利号:US-10975096-B2 优先权日:2014-06-20 标题 :Synthesis of polycyclic-carbamoylpyridone compounds 发明人:CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W 权利人:GILEAD SCIENCES INC 摘要:Methods of making compounds of Formula I are disclosed:
专利号:WO-2024178474-A1 优先权日:2023-03-02 标题 :Flow chemistry process for preparing aza-bicyclic heteroaryl compounds 发明人:WILLIAMS JASON DOUGLAS; PRIESCHL MICHAEL 权利人:ACTINOGEN MEDICAL LTD 摘要:The present disclosure relates to a continuous flow process for synthesis of heterocyclic methanone compounds, and in particular 3'-substituted, 3-hydroxyl-(8-aza- bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds, and aza-bicyclo intermediates thereof. In particular, the present disclosure also relates to a continuous flow process that can be utilised toward the synthesis of Xanamem.
[参考文献]: Young Ah Kim, Et Al. Synthesis, Biological Evaluation And Molecular Modeling Studies Of N6-Benzyladenosine Analogues As Potential Anti-Toxoplasma Agents. Biochem Pharmacol. 2007 May 15;73(10):1558-72.
合成参考文献
摘要:Shimizu, M.; Hiyama, T., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 604. 摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 331.