📜N-甲基甲酰胺,2,4-二甲基苯胺置于氯化亚砜体系中,用 甲苯 作为反应溶剂,以86.8%的收率获得产物单甲脒盐酸盐
参考文献:Arylformamidines With Antinociceptive Properties
标题:Arylformamidines With Antinociceptive Properties
摘要:A Series Of Formamidines Structurally Related To Clonidine Were Synthesized And Investigated As Potential Nonopiate Analgesics. Several Of These Compounds Showed Potent Analgesic Activity (Ed50 On Hcl Writhing Less Than 1.0 Mg/kg) With Low Potential For Hypotensive Effects. A Qualitative Description Of The Structure-Activity Relationship Of This Series Reveals That The 2,4-And 2,6-Dimethylphenyl Compounds Are More Potent Analgesics Than Are The Corresponding Dichlorophenyl Compounds.
DOI:10.1021/jm00117A023