CAS: 51-61-6; Dopamine
- 英文名称Dopamine
- 中文名称2-(3,4-二羟基苯基)乙胺
- IUPAC名称4-(2-aminoethyl)benzene-1,2-diol
- 其它别名2-(3,4-Dihydroxyphenyl)ethylamine; 3,4-Dihydroxyphenethylamine; 3-Hydroxytyramine
- CAS编号51-61-6
- MFCD编号:MFCD00130258
- EINECS号:200-110-0
- 分子式:C8H11NO2Lewis structure分子量:153.18
- 产品CID: 1506126
- 同类组份化合物CAS62-31-7 (HCl); 51-61-6 (free base)
- 产品分类原料药 → 循环系统用药 → 抗休克血管活性药
物理性质
- 熔点218-220 °C
- 沸点337.7±27.0 °C at 760 mmHg
- 闪点158.0±23.7 °C
- 密度1.2±0.1 g/cm3
- pKa:8.9(at 25°C)
- PSA:66.48
- LogP:0.12
- 折射率1.619
- 蒸汽压0.0±0.8 mmHg at 25°C
- 溶解性Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
- 敏感性多巴胺游离基在棱状结晶。对氧极敏感，遇氧很快自动氧化变色。
- 外观形态浅棕色至棕色固体
- 储存条件防潮, -20°C 冰箱, 在惰性气其中
- 产品应用该品为抗休克药物.
- 性质描述多巴胺游离基在棱状结晶.对氧极敏感,遇氧很快自动氧化变色.实际使用多巴胺盐酸盐,Dopaminehydr°Chloride,C8H11NO2·HCl,[62-31-7].盐酸盐为白色或类白色有光泽的结晶,熔点240-241°C(分解).易溶于水,溶于无水乙醇,微溶于氯仿;乙醚.在空气中及遇光色渐变深.无臭,味微苦.
MSDS等安全信息
- GHS象形图
- GHS符号GHS08 & GHS07 & GHS09;
注释: Health hazard & Exclamation mark & Environment - 危险类别生殖毒性 类别2
急性毒性 类别4(经口)
水生急性毒性 类别1
水生慢性毒性 类别1 - 警示词Warning(警告)
- 危险描述H361 |怀疑对生育能力或胎儿造成损害.
H302 |吞咽有害.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响. - 防范说明P273-P391-P501-P273-P391-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501
- 安全声明According to "Sax's Dangerous Properties of Industrial Materials" (by Richard J. Lewis, 2004 - DOI: 10.1002/0471701343), studies in rodents showed an LD50 (a lethal dose in 50% of subjects) between 59 to 163 mg/kg. In humans, dopamine can lead to peripheral vasoconstriction resulting in gangrenous extremities and cardiac arrhythmias. | Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. In the brain, dopamine actas as an agonist to the five dopamine receptor subtypes (D!, D2, D3, D4, D5).
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号59-92-7 左旋多巴 | CAS号121-33-5 香草醛 | CAS号554-52-9 3 Methoxytyramine | CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号50673-96-6 dopamine quinone | CAS号62-31-7 盐酸多巴胺 | CAS号37034-22-3 N-benzyloxycarb... | CAS号37627-79-5 N-(4-hydroxy-3-... | CAS号23699-77-6 N-叔丁氧羰基-3-O-甲基多巴胺 | CAS号105955-13-3 N-[2-(3,4-dihyd... | CAS号105955-12-2 N-linoleoyldopamine | CAS号105955-11-1 N-油酰多巴胺(ODA) | CAS号3131-52-0 5,6-二羟基吲哚 | CAS号67992-45-4 dopaminechrome | CAS号554-52-9 3 Methoxytyramine | CAS号3213-30-7 5-(2-氨基乙基)-2-甲氧基苯酚 | CAS号50673-96-6 dopamine quinone | CAS号50-53-3 氯丙嗪 | CAS号21581-49-7 4-(2-aminoethyl...合成工艺路线路线简述
📜对羟基苯乙胺置于氧气,Tyrosinase体系中,化学反应生成 多巴胺
参考文献:Facile Surface Immobilization Of Cell Adhesive Peptide Onto Tio2 Substrate Via Tyrosinase-Catalyzed Oxidative Reaction
标题:Facile Surface Immobilization Of Cell Adhesive Peptide Onto Tio2 Substrate Via Tyrosinase-Catalyzed Oxidative Reaction
摘要:研究人员开发了一种简便的方法,通过酪氨酸酶催化的氧化反应将生物活性分子(包括苯酚分子)固定到二氧化钛表面,从而实现生物材料的表面生物功能化.
DOI:10.1039/c1Jm13869C
海关参考信息
- 2902600000-乙苯
2907210001-间苯二酚
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Compound: Poly(dopamine)
摘要:HANSCH,C ET AL. (1995)
参考文献:10.1016/0022-3956(96)00007-6
摘要:Eklundh T, Eriksson M, Sjöberg S, Nordin C. Monoamine precursors, transmitters and metabolites in cerebrospinal fluid: a prospective study in healthy male subjects. Journal of Psychiatric Research. 1996 May;30(3):201–8. doi: 10.1016/0022-3956(96)00007-6.
📝 需求与反馈
尽可能描述清楚需求与问题信息
