CAS: 471-69-2; (5R,8R,9R,10R,13R,14R,17S)-17-((S)-2-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,8,10,14-Pentamethylhexadecahydro-3H-Cyclopenta[a]Phenanthren-3-One
该化合物是一种主要来自热带硬木树群的热带硬木树脂树脂的三肢类化合物,其特点是复杂的多环结构,有助于其显著的物理化学稳定性和生物活动.二百零八十六甲酚因其反炎和抗微生物特性,在制药研究中具有潜在的应用作用.它的疏水性使其适合脂质配方,而其结构僵化性在合成衍生药物开发方面提供了优势.该化合物在某些树脂提取物中的自然丰度也促进了可伸缩的孤立.目前正在进行进一步的研究,以探索其机械路径和治疗潜力.
- 英文名称(5R,8R,9R,10R,13R,14R,17S)-17-((S)-2-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,8,10,14-Pentamethylhexadecahydro-3H-Cyclopenta[a]Phenanthren-3-One
- 中文名称龙脑香醇酮
- IUPAC名称(5R,8R,9R,10R,13R,14R,17S)-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one
- 其它别名20-Hydroxy-5α-Dammar-24-En-3-One; 20-Hydroxydammara-24-Ene-3-One; (5R,8R,9R,10R,14R)-17-((S)-1-Hydroxy-1,5-Dimethyl-Hex-4-Enyl)-4,4,8,10,14-Pentamethyl-Hexadecahydro-Cyclopenta[a]Phenanthren-3-One; Dammar-24-En-3-One, 20-Hydroxy-; Dipterocaprol; Hydroxydamarenone Ii
- CAS编号471-69-2
- MFCD编号:MFCD00082553
- 分子式:C30H50O2分子量:442.73
- 产品CID: 1465766
- 产品分类天然产物 → 萜类
物理性质
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2006014729-A1
优先权日:2004-07-16
标 题 :Compounds and their preparation for the treatment of Alzheimer's disease by inhibiting beta-amyloid peptide production
发明人：LANDRY DONALD W; KIM TAE-WAN; DENG SHIXIAN
权利人:LANDRY DONALD W; KIM TAE-WAN; DENG SHIXIAN
摘要:The present invention provides novel dammarane compounds, compositions (e.g., pharmaceutical compositions) comprising the dammarane compounds, and methods for the synthesis of these dammarane compounds. Additionally, the present invention provides methods for inhibiting beta-amyloid peptide production and methods for treating or preventing a pathological condition, particularly, neurodegeneration diseases (e.g., Alzheimer's disease), using these dammarane compounds.
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📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of 2-Mono- And 2,2-Bis[2-(1H-Tetrazol-5-Yl)Ethyl] Derivatives Of Dipterocarpol作者:E. I. Rodionov,A. A. Kovaleva,A. D. Zorina,G. L. Starova,R. E. Trifonov |发布日期:2018.3
摘要:The Azidation Of 2,2-Bis(2-Cyanoethyl)-20-Hydroxydammar-24-En-3-One Afforded New Tetrazole Derivatives Of Natural Dipterocarpol, 2-(2-Cyanoethyl)-2-[2-(1H-Tetrazol-5-Yl)Ethyl]-20-Hydroxydammar-24-En- 3-Ones, 2,2-Bis[2-(1H-Tetrazol-5-Yl)Ethyl]-20-Hydroxydammar-24-En-3-One, And 2,2-Bis[2-(1H-Tetrazol-5-Yl)- Ethyl]-3-Oxo-25,26,27-Trinordammaran-(20S),24-Olide. The Structure Of The Final And Intermediate
合成参考文献
参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
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