CAS: 39746-00-4; (3Ar,4S,5R,6As)-4-(Hydroxymethyl)-2-Oxohexahydro-2H-Cyclopenta[b]Furan-5-Yl Benzoate

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CAS号39746-01-5 [3aR(3aa,4a,5b,... | CAS号101208-17-7 (-)-3-羰基-6-Β -三... | CAS号333963-40-9 鲁比前列酮 | CAS号39746-01-5 [3aR(3aa,4a,5b,... | CAS号69552-46-1 碳环素(碳环PGI 2) | CAS号32233-40-2 科立内脂二醇 | CAS号551-11-1 地诺前列素 | CAS号101208-17-7 (-)-3-羰基-6-Β -三... | CAS号84786-80-1 (3aR,4S,5R,6aS)... | CAS号64091-14-1 TBS-科里内酯醛

科立内脂二醇置于盐酸,4-二甲氨基吡啶,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,N,N-二异丙基乙胺体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 22.0H,反应生成 科里内酯
参考文献:苯甲酰科里内酯的制备方法
标题:苯甲酰科里内酯的制备方法
摘要:本发明提供一种制备高纯度式3所示化合物的方法,所述方法包括在二氯甲烷中,在二异丙基乙胺的存在下,用三乙基氯硅烷保护式4所示(‑)‑科里内酯的伯醇得到式3所示化合物,式中,R为三乙基氯硅烷;其中,式4所示(‑)‑科里内酯与三乙基氯硅烷的摩尔比为1‑1.5,式4所示(‑)‑科里内酯与二异丙基乙胺的摩尔比为1.5‑3;二氯甲烷与式4所示(‑)‑科里内酯的体积/质量(Ml/g)为3‑10;反应温度为20oc~30oc.本发明还提供利用得到的高纯度式3所示化合物制备式1所示的苯甲酰科里内酯的方法.本发明的方法选择性好,操作方便,易于工业化,从而能够高收率地制备(‑)‑苯甲酰科里内酯.

专利信息

专利号:US-8309744-B2
优先权日:2008-08-29
标题:Prostaglandin synthesis and intermediates for use therein
发明人：ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN
权利人:ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN; ALPHORA RES INC
摘要:Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: n nwherein R represents an aryl group such as p-methoxyphenyl.n n This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required α-side chain and then the required ω-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.

专利号:US-8513441-B2
优先权日:2008-08-29
标题:Prostaglandin synthesis and intermediates for use therein
发明人：ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN
权利人:ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN; ALPHORA RES INC
摘要:Fused cyclopentane-4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: n nwherein R represents an aryl group such as p-methoxyphenyl.n n This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required α-side chain and then the required ω-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.

专利号:US-7498458-B2
优先权日:2001-05-24
标 题 :Process for the preparation of prostaglandins and analogues thereof
发明人：GREENWOOD ALAN KENNETH; MCHATTIE DEREK; THOMPSON DAVID GEORGE; CLISSOLD DEREK
权利人:RESOLUTION CHEMICALS LTD
摘要:Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF2alpha.

专利号:US-8901319-B2
优先权日:2009-10-16
标题:Process for the preparation of F-series prostaglandins
发明人：CHAMBOURNIER GILLES; KORNILOV ANDRIY; MAHMOUD HUSSEIN M; VESELY IVAN; BARRETT STEPHEN D
权利人:CHAMBOURNIER GILLES; KORNILOV ANDRIY; MAHMOUD HUSSEIN M; VESELY IVAN; BARRETT STEPHEN D; CAYMAN CHEMICAL CO INC
摘要:A process for the synthesis and purification of F-series prostaglandin compounds and synthetic intermediates used to prepare them. The synthetic intermediates are solid and may be purified by precipitation and therefore may form the representative F-series prostaglandin compounds such as latanoprost, bimatoprost, fluprostenol, cloprostenol, and substituted analogs therefrom in highly pure forms.

专利号:CN-116947724-A
优先权日:2022-04-14
标 题:Synthesis method of latanoprost