CAS: 35890-38-1; (2S,4S,5R,6R)-5-Acetamido-2-(((2R,3S,4S,5R,6S)-3,5-Dihydroxy-2-(Hydroxymethyl)-6-(((2R,3R,4R,5R)-1,2,4,5-Tetrahydroxy-6-Oxohexan-3-yl)Oxy)Tetrahydro-2H-Pyran-4-yl)Oxy)-4-Hydroxy-6-((1R,2R)-1,2,3-Trihydroxypropyl)Tetrahydro-2H-Pyran-2-Carboxylic Acid

专利信息

专利号:US-2008145899-A1
优先权日:2004-09-17
标题 :Production of Oligosaccharides By Microorganisms
发明人：JOHNSON KARL; BYRNE NOEL J; DEFREES SHAWN
权利人:NEOSE TECHNOLOGIES INC
摘要:The present invention relates to the enzymatic synthesis of oligosaccharides, including sialylated product saccharides. In particular, it relates to the use of recombinant cells to take up low cost precursors such as glucose, pyruvate and N-actyl-glucosamine, and to synthesize activated sugar moieties that are used in oligosaccharide synthesis. The methods make possible the synthesis of many oligosaccharides using microorganisms and readily available, relatively inexpensive starting materials.

专利号:US-7608442-B2
优先权日:1999-02-01
标题:β1,3-galactosyltransferase polypeptides from the LOS locus of C. jejuni
发明人：GILBERT MICHEL; WAKARCHUK WARREN W
权利人:CA NAT RESEARCH COUNCIL
摘要:This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni . In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

专利号:US-6030815-A
优先权日:1995-04-11
标 题 :Enzymatic synthesis of oligosaccharides
发明人：DEFREES SHAWN; BAYER ROBERT J; RATCLIFFE MURRAY
权利人:NEOSE TECHNOLOGIES INC
摘要:The present invention provides improved methods for the preparation of sialyl galactosides. The methods use sialyl transferase cycle in which the reaction conditions are optimized to provide increased yields.

专利号:WO-9318787-A1
优先权日:1992-03-25
标 题 :Trans-sialidase and methods of use and making thereof
发明人：NUSSENZWEIG VICTOR; SCHENKMAN SERGIO; EICHINGER DAN; VANDEKERCKHOVE FLIP
权利人:UNIV NEW YORK
摘要:Polypeptides are provided having trans-sialidase enzymatic activity in substantially pure form, nucleic acids coding therefor, antibodies specific for such polypeptides, processes for producing the enzyme and methods of use of the enzyme, in particular for the synthesis of sialyl α(2â†?3)-linked saccharides, glycoproteins and glycolipids. Such enzymes are isolatable as nucleic acid or amino acid sequences from parasites of the genus Trypanosoma.

专利号:US-12123041-B2
优先权日:2018-09-21
标 题:Method for the production of amino sugar-containing products
发明人：MAERTENS JO; BAUWENS DAVID; VAN BELLEGEM WOUTER; COUSSEMENT PIETER; DUCHI DRIES; DE MEY MARJAN
权利人:UNIV GENT
摘要:A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.

专利号:US-5312747-A
优先权日:1990-12-17
标题:Isolation, purification and utilization of sialidase-L in the synthesis of 2,7-anhydro-N-acetylneuraminic acid and for the selective cleavage of sialylα2-3 D-galactose linkage
发明人：LI YU-TEH; LI SU-CHEN
权利人:LI YU TEH; LI SU CHEN
摘要:The instant invention relates to the isolation, purification and utilization of sialidase-L, a novel enzyme capable of producing 2,7-anhydro N-acetylneuraminic acid by the selective cleavage of sialic acid- alpha 2->3D-galactose glycosidic bonds. The instant invention also relates to a method for the preparation of 2,7-anhydro-N-acetylneuraminic acid using sialidase-L. The instant invention also relates to methods for selectively cleaving sialic acid- alpha 2->3D-galactose glycosidic linkages and providing a means to selectively destroy the selectin ligands for the treatment of selectin-mediated inflammation. The instant invention also relates to methods for using 2,7-anhydro-N-acetylneuraminic acid and sialidase-L for the selective sialylation of acceptor glycosides to form sialic acid- alpha 2->3D-galactose glycosidic linkages.