CAS: 23235-03-2; (R)-2-Aminopent-4-Ynoic Acid

该化合物是一种氨酸衍生物,其特点是其独特的烷基功能组,其特征为氨基酸衍生剂,其特性为五碳链,其中含有氨基氨基甲基苯组(-NH2),以及第四碳位置的终端烷基体(-CC-),该化合物一般为白色至白色固态,由于氨基基氨组的存在,可从事氢结合,在水中溶解,其结构允许其参与各种生物化学反应,使其有兴趣参与与氨基乙酸新陈代谢和合成生物学有关的研究,该烷基组的存在也为进一步的化学改造提供了机会,有可能导致新化合物的开发.作为手动分子,该物质以两种对应形式存在,其(R)配置与生物相关,其化学文摘社编号为2323235-03-2,用于化学数据库和监管背景下的识别.总体而言,(2R)-2-Amino-4-苯基酸是一种多种化合物,在研究和潜在治疗领域都应用.

结构式图片

相似化合物

87205-47-8 198561-07-8 220497-98-3

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

N-Acetyl-D-α-propargylglycine N-Acetyl-α-propargylglycine (R)-2-amino-4-pentynoic acid methyl ester (2R,5S)-5-isopropyl-3,6-dimethoxy-2-propargyl-2,5-dihydropyrazineB°C-L-Pra-OH 4,5-dideuterio-L-allylglycine (R)-2-amino-4-pentynoic acid methyl ester (R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pent-4-ynoic acid

合成工艺路线路线简述

    📜(R)-Methyl 2-Aminopent-4-Ynoate置于盐酸,Methyloxirane体系中,用84%的收率获得d-炔丙基甘氨酸
    参考文献:Schoellkopf; Hartwig; Pospischil,Synthesis,1981,Vol. No. 12,# 12,P. 966-969
    标题:Schoellkopf; Hartwig; Pospischil,Synthesis,1981,Vol. No. 12,# 12,P. 966-969

    海关参考信息

    专利信息


    专利号:WO-2024199465-A1
    优先权日:2023-03-30
    标 题:Unnatural amino acid in cellulo synthesis for site-specific protein modification
    发明人：CHAN MICHAEL KENNETH; LEE MARIANNE; CHENG JIAHUI
    权利人:UNIV HONG KONG CHINESE
    摘要:Provided are genetically modified host cells containing engineered enzymes that support the synthesis of unnatural amino acids, such as D-Cys-ε-Lys, and the incorporation of such unnatural amino acids into a newly synthesized protein. These cells are therefore capable of in vivo or in cellulo synthesis of a protein containing one or more unnatural amino acids strategically placed at pre-determined locations for site-specific modification of the protein. Also provided are the corresponding methods for in vivo synthesis of modified proteins as well as the modified proteins produced by the method.

    专利号:US-2020354404-A1
    优先权日:2019-05-09
    标 题 :Peptidomimetic agents, synthesis and uses thereof
    发明人：AL-ABED YOUSEF
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

    专利号:US-2021284668-A1
    优先权日:2018-06-19
    标题:Gold (i)-phosphine 1,2,3-triazole derivatives with antibiotic properties
    发明人：MISLIN GAËTAN; SCHALK ISABELLE; PLÉSIAT PATRICK; PAULEN AURÉLIE
    权利人:CENTRE NAT RECH SCIENT; UNIV FRANCHE COMTE; CENTRE HOSPITALIER REGIONAL UNIV DE BESANCON; UNIV STRASBOURG
    摘要:The present invention relates to gold (I)-phosphine 1,2,3-triazole compounds, and their use in a human or animal medicine. The present invention also relates to using such compounds for the prevention and/or treatment of an infection, i.e. inhibitors of growth of Gram-positive and/or Gram-negative bacteria. On another aspect the invention relates to the synthesis of the gold (I)-phosphine compounds of the invention and to their synthesis intermediates. The present invention finds applications in the medical, veterinary and/or chemical fields.

    专利号:US-10919882-B2
    优先权日:2019-05-09
    标题:Compounds for use in synthesis of peptidomimetics

    专利号:US-11414405-B2
    优先权日:2019-05-09
    标 题:Compounds for use in synthesis of peptidomimetics

    专利号:EP-3965770-A1
    优先权日:2019-05-09
    标 题 :Compounds for use in synthesis of peptidomimetics

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Hall, M.; Faber, K.; Tasnádi, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 305.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知