CAS: 22798-10-3; Disodium2-Hydroxybutanedioate

上下游产品

4-ethoxy-3-hydroxy-4-oxobutanoic acid sodium maleateOxalacetic acid

专利信息

专利号:WO-2023225524-A1
优先权日:2022-05-17
标题:Preparation of highly concentrated mrna
发明人：GENG MARK; SINOIMERI JAMES
权利人:MODERNATX INC
摘要:Provided herein are compositions of highly concentrated mRNA and related methods for preparation and use of the compositions as mRNA process intermediates in the synthesis of therapeutic and prophylactic mRNA formulations.

专利号:WO-2023108601-A1
优先权日:2021-12-13
标 题:Synthesis method for loxoprofen and analogues thereof
发明人：MEI YIJIANG; LI JIEPING; LI YONGGANG; YU SHUAI; HU KAI; WANG CHANGFA; WANG LUFENG
权利人:ZHEJIANG JIUZHOU PHARM CO LTD
摘要:A synthesis method for loxoprofen and analogues thereof as shown in the following reaction formula, wherein compound (I) undergoes a reaction under the catalysis of a catalyst to generate compound (II). The method avoids the use of a large amount of an acid solution and can be performed under solvent-free conditions, and therefore the method is more environmentally friendly. The used catalyst can be recycled and reused, the recovery rate of the catalyst reaches 98%, and the discharge of the three wastes and environmental pollution are greatly reduced.

专利号:US-6166253-A
优先权日:1996-04-05
标 题 :Process for producing N-(1-alkoxyethyl)carboxylic amides
发明人：AIZAWA TOSHIYUKI; NAKAMURA HITOSHI; KUDO TETSUO; MITARAI ETSUKO
权利人:SHOWA DENKO KK
摘要:A process for producing N-(1-alkoxyethyl)carboxylic amides by reacting alcohols of 1-5 carbon atoms with N-vinylcarboxylic amides in the presence of an acidic catalyst, or by utilizing unreacted starting material, unreacted intermediate or unrecovered product for synthesis of N-(1-alkoxyethyl)carboxylic amides. A process for producing N-(1-alkoxyethyl)carboxylic amides by adding a water-soluble strong acid during reaction between a carboxylic amide and a starting material containing acetaldehyde and alcohol and/or a starting material containing an acetal, in an amount of 2x10-3 to 3x10-1 equivalents to 1 mole of the carboxylic amide in the starting material, and using a strongly acidic ion-exchange resin as the catalyst.

专利号:US-5171886-A
优先权日:1990-11-15
标 题:Preparation of 2,2'-oxydisuccinate
发明人：SCHULTZ ROBERT G
权利人:MONSANTO CO
摘要:There is disclosed herein an improved processes for the preparation of oxydisuccinate by reacting in an alkaline reaction medium the salts of maleic acid and malic acid in the presence of a calcium ion catalyst wherein unreacted maleic acid salts are recovered from the reaction medium as sodium hydrogen maleate by lowering the pH of the reaction product to a range of from about 4 to 6. The precipitated sodium hydrogen maleate salts are recycled to the synthesis reaction as salts of malic acid by hydration in the presence of a hydration catalyst to prepare additional amounts of product.

专利号:WO-2021242807-A1
优先权日:2020-05-28
标题:Methods for preparing methyl (s)-2-amino-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propionate and hydrochloric acid salts thereof
发明人：POLISETTI DHARMA RAO; VICTORY SAMUEL
权利人:VTV THERAPEUTICS LLC
摘要:The invention provides methods for preparing key intermediates for the synthesis of (S)-2-(3S,8S)-3-(4-(3,4-dichlorobenzyloxy)phenyl-7-((S)-1-phenylpropyl)-2,3,6,7,8,9-hexahydro-[1,4]-dioxino[2,3-g]isoquinolin-8-ylformylamino)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propionic acid ('OAD2') and salts thereof. The key intermediates include methyl (S)-2-amino-3-[4-(2,3-dimethylpyridin-4-yl)-phenyl]-propionate and hydrochloric acid salts thereof. Compared with the prior art, the methods may not require column chromatographic separation and purification, and may have the advantages of potentially lower cost, higher yield, and suitability for industrial scale production.

专利号:CN-118479451-A
优先权日:2024-05-13
标题 :A method for ultrafast synthesis of carbon negative electrode materials for sodium batteries