CAS: 21834-92-4; 5-Methyl-2-Phenylhex-2-Enal

相似化合物

26643-92-5 26643-91-4 4411-89-6

上下游产品

CAS号6175-45-7 2,2-二乙氧基苯乙酮 | CAS号28322-40-9 三苯基溴化膦异戊酯

苯乙炔置于正丁基锂,氢气,Palladium Diacetate,C39H32I2Op2Pd体系中,用 四氢呋喃,正己烷,甲苯 用作溶剂,-40.0~70.0 °C,10.0 Mpa 条件下,反应 24.83H,反应生成5-甲基-2-苯基-2-己烯醛,(E)-2-Benzylidene-4-Methylpentanal
参考文献:碘配体辅助双核 Pd(I)-Pd(I) 催化烯烃和炔烃的选择性加氢甲酰化
标题:碘配体辅助双核 Pd(I)-Pd(I) 催化烯烃和炔烃的选择性加氢甲酰化
摘要:自 1938 年被发现以来,加氢甲酰化得到了彻底的研究并在工业中得到了广泛的应用(每年超过 107 公吨).然而,迄今为止,使用成熟的 Rh 或助催化剂精确控制其区域选择性的能力已被证明是难以捉摸的,从而限制了许多具有合成价值的醛的获得.钯催化剂代表了一种有吸引力的替代品,但由于不希望的副加工,它们的使用仍然很少.在这里,我们报告了一种高选择性和异常活性的催化剂系统,该系统由一种新型活化策略驱动,并具有独特的 Pd(I)-Pd(I) 机制,涉及碘化物辅助双核步骤以释放产物.这种方法能够对大范围的烯烃和炔烃(包括敏感的起始材料)进行 β 选择性加氢甲酰化.它的效用在抗肥胖药物利莫那班和抗 Hiv 药物 Pnu-32945 的合成中得到了证明.在更广泛的背景下,新的机理理解使其他对化学工业具有重要意义的羰基化反应的发展成为可能.
Doi:10.1021/jacs.0C09254

专利信息

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:US-4920232-A
优先权日:1987-07-10
标 题:α,β-substituted acroleins
发明人：GOETZ NORBERT; KARBACH STEFAN; RECKER HANS-GERT
权利人:BASF AG
摘要:Known and novel substituted acroleins of the general formula I ##STR1## where R 1 is alkoxy, phenoxy, halogen, haloalkyl, haloalkoxy, haloalkylthiyl or nitro, n is an integer from 1 to 5, in the case of n being greater than 1 the R 1 s being identical or different and in the event of nitro substitution the aromatic ring carrying not more than 3 nitro groups, and where R 2 is alkyl, cycloalkyl, unsubstituted or substituted aryl or hetaryl or a nonaromatic heterocyclic radical, are prepared by reacting a phenylacetaldehyde of the general formula II ##STR2## with an aldehyde of the general formula III n n [R.sup.2 -CHO] III n n in the presence of a base and a solvent. These acroleins are useful to prepare hydroxymethyloxiranes which are intermediates in the synthesis of antimycotic and fungicidal azoylmethyloxiranes.

专利号:WO-2021045879-A1
优先权日:2019-09-03
标 题 :Synthesis of deuterated aldehydes