CAS: 1678-98-4; Isobutylcyclohexane

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CAS号51284-25-4 3-(2-methylprop... | CAS号920-39-8 异丙基溴化镁 | CAS号2550-36-9 溴甲基环己烷 | CAS号538-93-2 异丁基苯 | CAS号91-17-8 十氢萘 | CAS号626-62-0 碘环己烷 | CAS号5674-02-2 异丁基氯化镁 | CAS号23747-22-0 1-[2-Methyl-pro... | CAS号1121-54-6 1,3-Cyclohexadi... | CAS号768-49-0 2-甲基-1-苯基丙烯 | CAS号702-79-4 1,3-二甲基金刚烷 | CAS号1687-36-1 1,3,5,7-四甲基金刚烷 | CAS号493-02-7 反-十氢化萘 | CAS号770-69-4 1-乙基金刚烷 | CAS号707-35-7 1,3,5-三甲基金刚烷 | CAS号768-91-2 1-甲基金刚烷

📜异丁酰苯置于氢气体系中,用 正庚烷 用作溶剂,150.0 °C,3.0 Mpa 条件下,反应 40.0H,以99%的收率获得异丁基环己烷
参考文献:使用金属-有机框架支持的单中心钴催化剂对芳烃进行化学选择性和串联还原
标题:使用金属-有机框架支持的单中心钴催化剂对芳烃进行化学选择性和串联还原
摘要:使用丰富的金属开发多相,化学选择性和串联催化系统对于精细和大宗化学品的可持续合成至关重要.我们报告了一种基于多孔铝金属有机骨架 (Dut-5 Mof) 的稳健且可回收的单中心钴氢化物催化剂,用于芳烃的化学选择性加氢.Dut-5 节点负载的氢化钴 (II) (Dut-5-Coh) 是一种多功能固体催化剂,用于化学选择性氢化一系列非极性和极性芳烃,包括杂芳烃,如吡啶,喹啉,异喹啉,吲哚和呋喃以优异的收率提供环烷烃和饱和杂环.Dut-5-Coh 表现出优异的官能团耐受性,可重复使用至少五次而不会降低活性.相同的 Mof-Co 催化剂也可有效用于芳基羰基化合物的串联加氢-加氢脱氧,包括生物质衍生的平台分子(如糠醛和羟甲基糠醛)生成环烷烃.在异丙苯加氢的情况下,我们的光谱,动力学和密度泛函理论 (Dft) 研究表明,在转换限制步骤中将三取代烯烃中间体插入到 Co-H 键中.我们的工作突出了 Mof
Doi:10.1021/acs.Inorgchem.1C03098

专利信息

专利号:US-7820858-B2
优先权日:2006-03-25
标 题 :Concise β2-amino acid synthesis via organocatalytic aminomethylation
发明人：CHI YONGGUI; GELLMAN SAMUEL H; POMERANTZ WILLIAM C; HORNE WILLIAM S; GUO LI; ENGLISH EMILY P
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides a method for the synthesis of β 2 -amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β 2 -amino acids.

专利号:US-6281245-B1
优先权日:1996-10-28
标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteinases).

专利号:US-6329519-B1
优先权日:1996-06-13
标 题:Intermediates for oligonucleotide synthesis
发明人：COLLINGWOOD STEPHEN PAUL; MOSER HEINZ ERNST; ALTMANN KARL-HEINZ; DOUGLAS MARK EDWARD
权利人:ISIS PHARMACEUTICALS INC
摘要:A compound of formula (I) wherein B 1 is a radical of a nucleoside base, R 1 is hydrogen or a hydroxy-protecting group, R 2 is hydrogen, hydroxy or a 2′-nucleoside-modifying atom or group, R 3 is an unsubstituted or substituted C 1 to C 10 alkyl, C 2 to C 10 alkenyl, C 4 to C 10 cycloalkylalkyl, C 6 to C 10 aryl or C 7 to C 13 aralkyl group, and Z is halogen or a group of formula (II) where R 4 and R 5 are each independently an unsubstituted or substituted C 1 to C 10 alkyl, C 2 to C 10 alkenyl, C 4 to C 10 cycloalkylalkyl, C 6 to C 10 aryl or C 7 to C 13 aralkyl group, or R 4 is said group and R 5 is hydrogen or R 4 and R 5 together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O—, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5′-hydroxyl group therefrom attached through a 5′-methylene thereof to the indicated oxygen atom.

专利号:US-6514997-B2
优先权日:1999-12-03
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU; JOHNNSON JR THEODORE O
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: n where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-6872745-B2
优先权日:2000-04-14
标 题 :Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：JOHNSON JR THEODORE O; HUA YE; LUU HIEP T; DRAGOVICH PETER S
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.