CAS: 1572-98-1; Ethyl 2-Cyano-2-Methylpropionate

相似化合物

5471-77-2 19295-57-9 1572-99-2

上下游产品

CAS号105-56-6 氰乙酸乙酯 | CAS号74-88-4 碘甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号1572-99-2 2-氰基丙酸乙酯 | CAS号74-87-3 氯甲烷 | CAS号75-93-4 methyl hydrogen... | CAS号109539-54-0 Propanoic acid,... | CAS号18852-51-2 sodium salt of ... | CAS号600-00-0 2-溴-2-甲基丙酸乙酯 | CAS号13435-20-6 氰化四乙基铵 | CAS号324763-51-1 3-氨基-2,2-二甲基丙酰胺 | CAS号173334-57-1 阿利吉仑 | CAS号180181-02-6 2,2-二甲基-3-(B°C-氨基)丙酸 | CAS号26734-09-8 3-氨基-2,2-二甲基-1-丙醇 | CAS号324763-47-5 (αS,γS,δS,ζS)-N... | CAS号19036-43-2 3-氨基-2,2二甲基乙酸 | CAS号22426-30-8 2-氰基-2-甲基丙酸 | CAS号19295-57-9 3-羟基-2,2-二甲基丙腈 | CAS号173338-07-3 [1S-[1R*(R*),2R... | CAS号7486-91-1 3,3-Dimethylaze...

📜氰乙酸乙酯置于溶剂黄146,硫酸二甲酯体系中,用 四氢呋喃,水 用作溶剂,以86.7%的收率获得2-氰基-2-甲基丙酸乙酯
参考文献:Synthetic Intermediate For Epothilone Derivative And Production Method Thereof
标题:Synthetic Intermediate For Epothilone Derivative And Production Method Thereof
摘要:这些化合物分别为&bgr;-酮酯化合物,&bgr;-羟基酸化合物和1,3-二醇衍生物的缩醛形式,其化学式分别为(I),(V)和(Viii),其中每个符号的定义见说明书,它们可作为一种合成中间体,用于开发作为抗肿瘤药物的依托酮衍生物.

专利信息

专利号:US-2012149895-A1
优先权日:2009-04-01
标题 :Process for dimethylation of active methylene groups
发明人：JENKO BRANKO; COPAR ANTON
权利人:JENKO BRANKO; COPAR ANTON; LEK PHARMACEUTICALS
摘要:The present invention discloses a process for dimethylation of active methylene groups. Specifically, the invention discloses a process for preparing 3-amino-2,2-dimethylpropanamide. Compounds produced by the present dimethylation process such as 3-amino-2,2-dimethylpropanamide can be used as intermediates in the route of synthesis of therapeutic, prophylactic or diagnostic agent, for example aliskiren or cryptophycin. Particularly, the invention relates to embodiments further extending to processes for preparing pharmaceutical dosage form comprising said therapeutic, prophylactic or diagnostic agents. More specifically, the invention relates to the use of compounds produced by the present dimethylation process for the manufacture of therapeutic, prophylactic or diagnostic agents or for the manufacture of pharmaceutical dosage forms comprising said therapeutic, prophylactic or diagnostic agents. The processes according to the present invention can be beneficially applied for the synthesis of various active pharmaceutical ingredients, such as aliskiren or crypthophycin.

专利号:WO-2011148392-A1
优先权日:2010-05-28
标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.

专利号:US-2007191395-A1
优先权日:2004-02-16
标题 :Heterocyclic compounds having antifungal activity
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
权利人:KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
摘要:A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.