CAS: 14777-27-6; Methyl Acetimidate Hydrochloride

上下游产品

CAS号67-56-1 甲醇 | CAS号75-05-8 乙腈 | CAS号5652-84-6 氰基甲酯 | CAS号1769-24-0 2-甲基-4(1H)-喹唑啉酮 | CAS号21119-13-1 O-methyl ethane... | CAS号60-35-5 乙酰胺 | CAS号74-87-3 氯甲烷 | CAS号95-21-6 2-甲基苯并唑 | CAS号73-67-6 4-氨基-2-甲基-5-嘧啶甲醇 | CAS号698-29-3 2-甲基-4-氨基嘧啶-5-腈 | CAS号155884-28-9 4,5-二氢-2-甲基-1,3... | CAS号1445-45-0 原乙酸三甲酯

📜甲醇,乙腈置于盐酸体系中,用 正己烷 用作溶剂,化学反应 3.0H,以75%的收率获得甲基乙酰亚胺酯盐酸盐
参考文献:A Facile And Versatile Route To 2-Substituted-4(3H)-Quinazolinones And Quinazolines
标题:A Facile And Versatile Route To 2-Substituted-4(3H)-Quinazolinones And Quinazolines
摘要:通过简单,温和的一锅式反应,我们从蚁酸和适当取代的亚胺酯反应中制备出了一系列 2-芳基和 2-烷基喹唑啉酮,收率从中等到非常好.随后与氧氯化磷反应,可以得到相应的 4-氯-2-取代喹唑啉类化合物,它们是有用的合成中间体,收率从好到高.为这两个反应开发的工作程序不包括柱层析纯化,从而促进了产品的分离.
Doi:10.1055/s-2001-18080

专利信息

专利号:US-6407103-B2
优先权日:1998-04-21
标 题:Indeno [1,2-c] pyrazol-4-ones and their uses
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:EP-3845540-A1
优先权日:2013-03-13
标题 :Intermediates for the synthesis of benzoxazepin compounds