CAS: 13737-36-5; 4-(Bromomethyl)Phenylacetic Acid

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7398-42-7 7371-94-0 96044-43-8

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CAS号622-47-9 对甲苯乙酸 | CAS号94-36-0 过氧化苯甲酰 | CAS号34241-39-9 2-(2-cyanopropa... | CAS号176504-01-1 Fm°C-(4-氨基甲基苯基)乙酸 | CAS号189287-72-7 Diethyl 2-[4-(2... | CAS号193290-61-8 methyl 2-[4-(cy... | CAS号343880-24-0 4-(甲氧甲基)苯乙酸 | CAS号96524-70-8 4-甲酰基苯乙酸甲酯 | CAS号223123-57-7 4-(2,2-Dicarboe... | CAS号223123-63-5 4-(2,2-Dicarboe... | CAS号73401-74-8 4-(羟甲基)苯乙酸 | CAS号7398-42-7 4-溴甲基苯乙酸甲酯 | CAS号66270-97-1 4-(溴甲基)苯乙酸苯甲酰甲酯

📜对甲基苯乙酸置于偶氮二异丁腈,溴体系中,用 四氯化碳 用作溶剂,化学反应 0.08H,以62%的收率获得4-(溴甲基)苯乙酸
参考文献:具有灵活但预先组织的几何形状的高功能化三足肽的固体支持合成:走向潜在的丝氨酸蛋白酶模拟物
标题:具有灵活但预先组织的几何形状的高功能化三足肽的固体支持合成:走向潜在的丝氨酸蛋白酶模拟物
摘要:三足支架 1 已用于合成丝氨酸蛋白酶模拟库的代表性成员,在中央核心上拥有三个独立的功能化肽链.每条肽链都包含在丝氨酸蛋白酶 α-胰凝乳蛋白酶的活性位点中发现的经典催化三联体(丝氨酸,组氨酸和天冬氨酸)的一个残基.新型三脚架设计的一个特点是其本质上灵活但预先组织的结构,正如从分子建模研究中推断出来的.对合适的支架和侧链保护基团的选择进行了深入研究和优化,以确保完全正交.
Doi:10.1002/ejoc.200600145

专利信息

专利号:US-6815214-B2
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of diketopiperazines
发明人：BOYCE JIM P; HOWBERT J JEFFRY; TABONE JOHN C
权利人:CELLTECH R & D INC
摘要:The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-α, TNF-β and also apoptosis.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-5886104-A
优先权日:1993-06-18
标题 :Grafted cross-linked polyolefin substrates for peptide synthesis and assays
发明人：PEDERSEN WALTHER BATSBERG; ALMDAL KRISTOFFER; WINTHER LARS; BERG ROLF HENRIK
权利人:FORSKNIINGSCENTER RISO
摘要:A solid support for the solid-phase synthesis of peptides or proteins in high yield and in high purity, suited both to the synthesis of a single peptide or protein and to the parallel and substantially simultaneous synthesis of a plurality thereof, is based on a cross-linked polyolefin, especially polyethylene, substrate, the cross-linking having been obtained by irradiation with high energy electrons or γ radiation or treatment with organic peroxide such as benzoyl peroxide, to which substrate are grafted polymer chains such as polystyrene chains which are functionalized with a chemical functionality facilitating the formation of an anchoring linkage between the polymer moiety and another chemical species. The solid support is also suited for use in solid-phase biosystems, notably bioassays, such as immunoassays, DNA hybridization assays or PCR amplification. The grafted chains may bear substituents which are such that the polymer-grafted cross-linked polyolefin substrate is swellable by water or aqueous media, in other words, hydrophilic, which makes the solid support particularly well suited for assays of the ELISA type.

专利号:US-5373053-A
优先权日:1988-09-01
标 题:Peptide synthesis method and solid support for use in the method
发明人：BERG ROLF H; ALMDAL KRISTOFFER; PEDERSEN WALTHER B; HOLM ARNE; TAM JAMES P; MERRIFIELD ROBERT B
权利人:RISO NAT LAB
摘要:A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not including optional non-reactive substituents, of at least 200,000, preferably in the range of 600,000-1,200,000. Particularly suitable polymer substrates are substrates of a polyolefin such as polyethylene. The method is particularly well-suited to the compartmentalized synthesis of a multitude of peptides or proteins in a parallel and substantially simultaneous fashion. n Preferred embodiments of a solid support for performing the synthesis are prepared from thin polyethylene sheet or film which has been grafted with polystyrene chains in a radical-initiated process in which the polyethylene sheet or film is immersed in a solution of optionally substituted styrene monomer in an alcohol such as methanol, the volume percentage of styrene in the solution preferably being about 30% v/v, and subjected to gamma irradiation.

专利号:EP-0433345-B1
优先权日:1988-09-01
标题:Peptide synthesis method and solid support for use in the method
发明人：BERG ROLF H; ALMDAL KRISTOFFER; PEDERSEN WALTHER BATSBERG; HOLM ARNE; TAM JAMES P; MERRIFIELD ROBERT BRUCE
权利人:RISOE FORSKNINGSCENTER
摘要:A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not including optional non-reactive substituents, of at least 200,000, preferably in the range of 600,000-1,200,000. Particularly suitable polymer substrates are substrates of a polyolefin such as polyethylene. The method is particularly well-suited to the compartmentalized synthesis of a multitude of peptides or proteins in a parallel and substantially simultaneous fashion. Preferred embodiments of a solid support for performing the synthesis are prepared from thin polyethylene sheet or film which has been grafted with polystyrene chains in a radical-initiated process in which the polyethylene sheet or film is immersed in a solution of optionally substituted styrene monomer in an alcohol such as methanol, the volume percentage of styrene in the solution preferably being about 30 % v/v, and subjected to gamma irradiation.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.