CAS: 13513-82-1; 1-(2-Methoxyphenyl)Ethanol

相似化合物

108100-06-7 579-74-8 113724-48-4

上下游产品

CAS号579-74-8 2'-甲氧基苯乙酮 | CAS号67-63-0 异丙醇 | CAS号614-45-9 过氧化苯甲酸叔丁酯 | CAS号14804-32-1 2-乙基苯甲醚 | CAS号75-24-1 三甲基铝 | CAS号135-02-4 邻甲氧基苯甲醛 | CAS号612-15-7 2-甲氧基苯乙烯 | CAS号917-54-4 甲基锂 | CAS号695-84-1 2-乙烯基苯酚 | CAS号41453-01-4 Methylniobtetra... | CAS号40023-74-3 1-(2-甲氧基苯基)乙胺 | CAS号321-28-8 2-氟苯甲醚 | CAS号90-00-6 2-乙基苯酚 | CAS号612-15-7 2-甲氧基苯乙烯 | CAS号14804-32-1 2-乙基苯甲醚 | CAS号223375-01-7 1-(1-溴乙基)-2-甲氧基苯 | CAS号22233-80-3 Hydrazinecarbox... | CAS号90-05-1 愈创木酚 | CAS号52193-85-8 (R)-(+)-1-(2-萘基)乙醇 | CAS号579-74-8 2'-甲氧基苯乙酮

📜(R)-1-(2-Methoxyphenyl)Ethyl Acetate置于sodium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 0.08H,反应生成(R)-1-(2-甲氧基苯基)乙醇
参考文献:Rapid,Room-Temperature Acylative Kinetic Resolution Of Sec-Alcohols Using Atropisomeric 4-Aminopyridine/triphenylphosphine Catalysis
标题:Rapid,Room-Temperature Acylative Kinetic Resolution Of Sec-Alcohols Using Atropisomeric 4-Aminopyridine/triphenylphosphine Catalysis
摘要:Two New Atropisomeric 4-Aminopyridine-Based Nucleophilic Catalysts Containing Terphenyl 'Blocking Groups' Have Been Prepared And Evaluated For Kinetic Resolution (Kr) Of Aryl Alkyl Sec-Alcohols. One Of These Biaryls Is Shown To Be The Most Selective Atropisomeric Catalyst Yet Prepared For Several Sec-Alcohols But Its Low Reactivity Makes It Non-Optimal For Use At Room Temperature (Rt). Optimisation Of The Conditions For Conducting Krs At Rt Using A Previously Described Catalyst (Containing A Phenyl Blocking Group) At The 1 Mol% Level Indicates That Pph3 (1 Equiv) Is Beneficial For Enantioselectivity And Allows Kr Of (+/-)-1-(Naphthyl)Ethanol In Less Than 30 Min With S > 15 (I.E. Similar To 40% Recovered Alcohol With > 95% Ee). These Conditions Constitute A Convenient And Practical Method For Rapid Kr Of Sec-Alcohols And Are Anticipated To Facilitate A Detailed Kinetic Study Of This Catalytic Manifold By Calorimetry. (C) 2005 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2005.08.124

专利信息

专利号:US-6080874-A
优先权日:1997-09-25
标题:Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydroxyurea
发明人：HENGEVELD JOHN E; LEESE ELISE H; MOON BRIAN S; ABAD DENNIS M; ALLEN KIMBERLY A; BAUER PHILIP E; MURPHEY DAVID B; FOHEY BRIAN T; COPP JR RICHARD R; LANNOYE GREG S; MITTAG RODNEY M
权利人:ABBOTT LAB
摘要:The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[b]thienyl substituted N-hydroxyurea of formula: from compound 1: by reacting compound 1 with hydroxyurea and acid. R1 is selected from the group consisting of hydrogen, 1-6 carbon alkyl, 1-6 carbon alkoxy, and halogen; R2 is an 1-4 carbon alkyl; and R3 is selected from the group consisting of hydrogen, acyl, methyl, ethyl and mixtures thereof. Additional steps to isolate the pure bulk product follow.