CAS: 1218935-59-1; (R)-2-(2,5-Difluorophenyl)Pyrrolidine

相似化合物

1218935-60-4 1217630-38-0 886503-15-7

上下游产品

2-(2,5-二氟苯基)吡咯烷 2-(2,5-Difluorophenyl)Pyrrolidine 886503-15-7
(R)-2-(2,5-二氟苯基)吡咯烷-1-羧酸叔丁酯 R-N-Boc-2-(2,5-Difluorophenyl)-Pyrrolidine 1218935-58-0
(R)-1-((S)-Tert-Butylsulfinyl)-2-(2,5-Difluorophenyl)Pyrrolidine 1443538-31-5

1,4-二氟苯置于硼烷四氢呋喃络合物,甲烷磺酸,四磷十氧化物,Eaton's Reagent,O,O'-Dibenzoyl-L-Tartaric Acid体系中,用 四氢呋喃,正丁醇 用作溶剂,化学反应 38.0H,反应生成(R)-2-(2,5-二氟苯基)吡咯烷
参考文献:一种拉洛替尼中间体(2R)-2-(2,5-二氟苯基) 吡咯烷的合成方法
标题:一种拉洛替尼中间体(2R)-2-(2,5-二氟苯基) 吡咯烷的合成方法
摘要:本发明公开一种拉洛替尼中间体(2R)‑2‑(2,5‑二氟苯基)吡咯烷的合成方法,属于药物合成领域.本发明以对二氟苯和l‑焦谷氨酸原料在伊顿试剂作用下得到中间体i,中间体i经过还原得到中间体ii,再经过手性拆分得到(2R)‑2‑(2,5‑二氟苯基)吡咯烷;本发明合成路线短,反应条件温和,原料廉价易得,收率高,产品纯度好.

专利信息

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:CN-114836490-A
优先权日:2022-04-29
标题:Application of an imine reductase in catalytic synthesis of chiral 2-arylpyrrolidines

专利号:CN-114774383-B
优先权日:2022-04-29
标题 :A class of imine reductase mutants and their application in catalytic synthesis of chiral 2-arylpyrrolidines

专利号:DK-2725028-T3
优先权日:2008-10-22
标题:Substituted pyrazolo [1,5-a] pyrimidine compounds as intermediates in the synthesis of kinase inhibitors TRK

专利号:EP-2725028-A1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:EP-2725028-B1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors